Design, synthesis and biological evaluation of acyl hydrazones-based derivatives as RXRα-targeted anti-mitotic agents.

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作者： Qiqiang,Wang ^[1] ; Xuhuang,Tu ^[1] ; Xin,Wang ^[1] ; Qi,Cai ^[1] ; Liangfa,Yu ^[1] ; Xuan,Zhang ^[1] ; Jiajin,Yi ^[1] ; Yuhang,Wu ^[1] ; Guobin,Xie ^[1] ; Hang,Yuan ^[1] ; Mingyu,Li ^[1] ; Xiaokun,Zhang ^[1] ; Zhiping,Zeng ^[2] ; Ying,Su ^[3]

作者单位： School of Pharmaceutical Sciences, Fujian Provincial Key Laboratory of Innovative Drug Target Research, Xiamen University, Xiamen 361102, China. ^[1] School of Pharmaceutical Sciences, Fujian Provincial Key Laboratory of Innovative Drug Target Research, Xiamen University, Xiamen 361102, China. Electronic address: zengzhiping@xmu.edu.cn. ^[2] School of Pharmaceutical Sciences, Fujian Provincial Key Laboratory of Innovative Drug Target Research, Xiamen University, Xiamen 361102, China; NucMito Pharmaceuticals Co. Ltd., Xiamen 361100, China. Electronic address: ying.su@nucmito.com. ^[3]

关键词 Acyl hydrazones Mitosis Nuclear Receptors PLK1 RXRα

主题词细胞凋亡(Apoptosis);中心体(Centrosome);人类(Humans);腙类(Hydrazones);有丝分裂(Mitosis)

DOI 10.1016/j.bioorg.2022.106069

PMID 35964501

发布时间 2022-09-16

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