SILAC-based chemoproteomics reveals a neoligan analogue as an anti-inflammatory agent targeting IRGM to ameliorate cytokine storm.

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作者： Jichao,Zhang ^[1] ; Yang,Li ^[1] ; Guibing,Meng ^[1] ; Kui,Lu ^[2] ; Jiankun,Yan ^[1] ; Jiangpeng,Wu ^[1] ; Pengyan,Li ^[1] ; Lingling,Luo ^[1] ; Xi,Chen ^[3] ; Xia,Zhao ^[4] ; Feng,Qiu ^[5]

作者单位： School of Chinese Materia Medica, and State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China. ^[1] China International Science and Technology Cooperation Base of Food Nutrition/Safety and Medicinal Chemistry, College of Biotechnology, Tianjin University of Science & Technology, Tianjin, 300457, China. ^[2] School of Chinese Materia Medica, and State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China. Electronic address: Chenxi2014@tjutcm.edu.cn. ^[3] College of Chemistry, Tianjin Normal University, Tianjin, 300387, China. Electronic address: hxxyzhx@mail.tjnu.edu.cn. ^[4] School of Chinese Materia Medica, and State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China. Electronic address: fengqiu20070118@163.com. ^[5]

关键词 Chemoproteomics Cytokine storm IRGM Neoligan SILAC

主题词动物(Animals);消炎药(Anti-Inflammatory Agents);细胞因子类(Cytokines);疾病模型, 动物(Disease Models, Animal);GTP结合蛋白质类(GTP-Binding Proteins);人类(Humans);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);蛋白质组学(Proteomics);脓毒症(Sepsis)

DOI 10.1016/j.ejmech.2022.114659

PMID 35970074

发布时间 2022-12-21

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European journal of medicinal chemistry

2022年241卷

114659页

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SILAC-based chemoproteomics reveals a neoligan analogue as an anti-inflammatory agent targeting IRGM to ameliorate cytokine storm.

European journal of medicinal chemistry

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European journal of medicinal chemistry

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SILAC-based chemoproteomics reveals a neoligan analogue as an anti-inflammatory agent targeting IRGM to ameliorate cytokine storm.

European journal of medicinal chemistry

相似文献

European journal of medicinal chemistry

相关期刊

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