首页> Journal of medicinal chemistry> Discovery of Substituted Di(pyridin-2-yl)-1,2,4-thiadiazol-5-amines as Novel Macrofilaricidal Compounds for the Treatment of Human Filarial Infections.

Discovery of Substituted Di(pyridin-2-yl)-1,2,4-thiadiazol-5-amines as Novel Macrofilaricidal Compounds for the Treatment of Human Filarial Infections.

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第一作者： Natalie,Hawryluk

第一单位： Bristol Myers Squibb, San Diego, California 92121, United States.

作者： Natalie,Hawryluk ^[1] ; Dale,Robinson ^[1] ; Yixing,Shen ^[1] ; Graham,Kyne ^[2] ; Matthew,Bedore ^[2] ; Sanjay,Menon ^[2] ; Stacie,Canan ^[1] ; Thomas,von Geldern ^[3] ; Simon,Townson ^[4] ; Suzanne,Gokool ^[4] ; Alexandra,Ehrens ^[5] ; Marianne,Koschel ^[6] ; Nathaly,Lhermitte-Vallarino ^[7] ; Coralie,Martin ^[7] ; Achim,Hoerauf ^[5] ; Geraldine,Hernandez ^[1] ; Deepak,Dalvie ^[1] ; Sabine,Specht ^[8] ; Marc Peter,Hübner ^[5] ; Ivan,Scandale ^[9]

作者单位： Bristol Myers Squibb, San Diego, California 92121, United States. ^[1] Zoetis, Kalamazoo, Michigan 49001, United States. ^[2] Embedded Consulting, Richmond, Illinois 60071, United States. ^[3] Northwick Park Institute for Medical Research, London HA1 3UJ, UK. ^[4] Institute for Medical Microbiology, Immunology & Parasitology, University Hospital Bonn, 53127 Bonn, Germany.;German Center for Infection Research (DZIF), partner site Bonn-Cologne, 53127 Bonn, Germany. ^[5] Institute for Medical Microbiology, Immunology & Parasitology, University Hospital Bonn, 53127 Bonn, Germany. ^[6] Unité Molécules de Communication et Adaptation des Microorganismes (MCAM, UMR 7245), Muséum national d'Histoire Naturelle, Paris 75005, France. ^[7] Institute for Medical Microbiology, Immunology & Parasitology, University Hospital Bonn, 53127 Bonn, Germany.;Drugs for Neglected Diseases Initiative, Geneva 1204, Switzerland. ^[8] Drugs for Neglected Diseases Initiative, Geneva 1204, Switzerland. ^[9]

医学主题词成年人(Adult);胺类(Amines);象皮病, 丝虫性(Elephantiasis, Filarial);人类(Humans);盘尾丝虫病(Onchocerciasis)

DOI 10.1021/acs.jmedchem.2c00960

PMID 35972896

发布时间 2022-09-22

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