Proximity labeling of endogenous RICTOR identifies mTOR complex 2 regulation by ADP ribosylation factor ARF1.

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作者： Amelia K,Luciano ^[1] ; Ekaterina D,Korobkina ^[1] ; Scott P,Lyons ^[2] ; John A,Haley ^[1] ; Shelagh M,Fluharty ^[1] ; Su Myung,Jung ^[1] ; Arminja N,Kettenbach ^[3] ; David A,Guertin ^[4]

作者单位： Program in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA. ^[1] Department of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA. ^[2] Department of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA; Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA. ^[3] Program in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA. Electronic address: David.Guertin@umassmed.edu. ^[4]

关键词 ADP ribosylation factor Akt/PKB BioID2 RICTOR cell signaling growth factor mTORC2 mammalian target of rapamycin proximity labeling

主题词人类(Humans);ADP核糖基化因子1(ADP-Ribosylation Factor 1);胰岛素(Insulin);磷酰化(Phosphorylation);原癌基因蛋白质c-akt(Proto-Oncogene Proteins c-akt);TOR丝氨酸-苏氨酸激酶(TOR Serine-Threonine Kinases);蛋白质相互作用图谱(Protein Interaction Mapping)

DOI 10.1016/j.jbc.2022.102379

PMID 35973513

发布时间 2022-11-30

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