Metabolic, genetic, and pharmacokinetic parameters for the prediction of olanzapine efficacy.

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第一作者： Ling,Cong

第一单位： Pharmacy Department of Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, PR China.

作者： Ling,Cong ^[1] ; Zirui,Wan ^[1] ; Pengfei,Li ^[1] ; Dan,Liu ^[2] ; Jiuming,He ^[3] ; Zhuoling,An ^[4] ; Lihong,Liu ^[1]

作者单位： Pharmacy Department of Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, PR China. ^[1] State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100050, PR China. ^[2] State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100050, PR China. Electronic address: hejiuming@imm.ac.cn. ^[3] Pharmacy Department of Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, PR China. Electronic address: anzhuoling@163.com. ^[4]

关键词 Individualized medication Olanzapine Pharmacogenomics Pharmacokinetics Pharmacometabonomics

主题词色谱法, 液相(Chromatography, Liquid);葡糖醛酸基转移酶(Glucuronosyltransferase);人类(Humans);多态性, 单核苷酸(Polymorphism, Single Nucleotide);γ氨基丁酸(gamma-Aminobutyric Acid)

DOI 10.1016/j.ejps.2022.106277

PMID 35981664

发布时间 2022-09-07

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