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Uncovering the roles of dihydropyrimidine dehydrogenase in fatty-acid induced steatosis using human cellular models.

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第一作者： Kelly E,Sullivan

第一单位： Translational Systems Biology Group, Amgen Inc., Cambridge, MA, 02141, USA.;Vertex Pharmaceuticals, Boston, MA, 02210, USA.

作者： Kelly E,Sullivan ^[1] ; Sheetal,Kumar ^[2] ; Xin,Liu ^[3] ; Ye,Zhang ^[3] ; Emily,de Koning ^[4] ; Yanfei,Li ^[5] ; Jing,Yuan ^[6] ; Fan,Fan ^[7]

作者单位： Translational Systems Biology Group, Amgen Inc., Cambridge, MA, 02141, USA.;Vertex Pharmaceuticals, Boston, MA, 02210, USA. ^[1] Translational Systems Biology Group, Amgen Inc., Cambridge, MA, 02141, USA.;Nimbus Therapeutics, Cambridge, MA, 02139, USA. ^[2] Translational Systems Biology Group, Amgen Inc., Cambridge, MA, 02141, USA.;Novartis Institutes for Biomedical Research, Cambridge, MA, 02139, USA. ^[3] Translational Systems Biology Group, Amgen Inc., Cambridge, MA, 02141, USA.;Amgen Inc., Thousand Oaks, CA, 91320, USA. ^[4] Amgen Inc., South San Francisco, CA, 90408, USA. ^[5] Translational Systems Biology Group, Amgen Inc., Cambridge, MA, 02141, USA.;Pfizer Inc., Cambridge, MA, 02139, USA. ^[6] Translational Systems Biology Group, Amgen Inc., Cambridge, MA, 02141, USA. fan.fan.enzyme@gmail.com.;Janssen Pharmaceutical Companies of Johnson & Johnson, La Jolla, CA, 92037, USA. fan.fan.enzyme@gmail.com. ^[7]

医学主题词二氢尿嘧啶脱氢酶(NADP)(Dihydrouracil Dehydrogenase (NADP));脂肪酸类(Fatty Acids);氟尿嘧啶(Fluorouracil);人类(Humans);尿嘧啶(Uracil)

DOI 10.1038/s41598-022-17860-2

PMID 35982095

发布时间 2022-10-26

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