Phenotypic Screening of Histone Deacetylase (HDAC) Inhibitors against Schistosoma mansoni.

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作者： Muhammad Murtaza,Hassan ^[1] ; Abootaleb,Sedighi ^[2] ; Olasunkanmi O,Olaoye ^[1] ; Cécile,Häberli ^[2] ; Annika,Merz ^[1] ; Elizabeth,Ramos-Morales ^[2] ; Elvin D,de Araujo ^[3] ; Christophe,Romier ^[4] ; Manfred,Jung ^[5] ; Jennifer,Keiser ^[6] ; Patrick T,Gunning ^[7]

作者单位： Department of Chemical and Physical Sciences, University of Toronto Mississauga, 3359 Mississauga Road North, Mississauga, ON L5L 1C6, Canada. ^[1] Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, ON M5S 3H6, Canada. ^[2] Swiss Tropical and Public Health Institute, 4123, Allschwil, Switzerland. ^[3] University of Basel, 4003, Basel, Switzerland. ^[4] Institute of Pharmaceutical Sciences, Albert-Ludwigs-Universität Freiburg, Albertstr. 25, 79104, Freiburg, Germany. ^[5] Université de Strasbourg, CNRS, INSERM, Institut de Génétique et de Biologie Moléculaire et Cellulaire, UMR 7104, U 1258, 67400, Illkirch, France. ^[6] Department of Integrated Structural Biology IGBMC, 1 rue Laurent Fries, B.P. 10142, 67404, Illkirch Cedex, France. ^[7]

关键词 HDAC inhibitors HDAC8 selective Schistosoma mansoni epigenetic therapy schistosomiasis