N-terminus of Etanercept is Proteolytically Processed by Dipeptidyl Peptidase-4.

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作者： Sho,Masui ^[1] ; Atsushi,Yonezawa ^[2] ; Kotoko,Yokoyama ^[3] ; Noriko,Iwamoto ^[4] ; Takashi,Shimada ^[5] ; Akira,Onishi ^[5] ; Hideo,Onizawa ^[5] ; Takayuki,Fujii ^[6] ; Kosaku,Murakami ^[6] ; Koichi,Murata ^[6] ; Masao,Tanaka ^[7] ; Shunsaku,Nakagawa ^[8] ; Daiki,Hira ^[9] ; Kotaro,Itohara ^[6] ; Satoshi,Imai ^[7] ; Takayuki,Nakagawa ^[6] ; Makoto,Hayakari ^[1] ; Shuichi,Matsuda ^[1] ; Akio,Morinobu ^[1] ; Tomohiro,Terada ^[1] ; Kazuo,Matsubara ^[1]

作者单位： Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan. ^[1] Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan. ^[2] Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan. ayone@kuhp.kyoto-u.ac.jp. ^[3] Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan. ayone@kuhp.kyoto-u.ac.jp. ^[4] Shimadzu Corporation, Kyoto, Japan. ^[5] Department of Advanced Medicine for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan. ^[6] Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan. ^[7] Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan. ^[8] Center for Cancer Immunotherapy and Immunobiology, Graduate School of Medicine, Kyoto University, Kyoto, Japan. ^[9]

关键词 LC–MS/MS N-terminal truncation biotransformation dipeptidyl peptidase-4 etanercept