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Neuronal network-based biomimetic chip for long-term detection of olfactory dysfunction model in early-stage Alzheimer's disease.

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第一作者： Mengxue,Liu

第一单位： Biosensor National Special Laboratory, Key Laboratory for Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou, 310027, China; The MOE Frontier Science Center for Brain Science & Brain-machine Integration, Zhejiang University, Hangzhou, 310027, China.

作者： Mengxue,Liu ^[1] ; Changming,Chen ^[1] ; Keqiang,Gao ^[2] ; Fan,Gao ^[3] ; Chunlian,Qin ^[4] ; Qunchen,Yuan ^[4] ; Hong,Zhang ^[4] ; Liujing,Zhuang ^[5] ; Ping,Wang ^[6]

作者单位： Biosensor National Special Laboratory, Key Laboratory for Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou, 310027, China; The MOE Frontier Science Center for Brain Science & Brain-machine Integration, Zhejiang University, Hangzhou, 310027, China. ^[1] School of Pharmacy, Nanjing Medical University, Nanjing, 211166, China. ^[2] Department of Biomedical Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing, 210016, China. ^[3] Biosensor National Special Laboratory, Key Laboratory for Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou, 310027, China. ^[4] Biosensor National Special Laboratory, Key Laboratory for Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou, 310027, China; The MOE Frontier Science Center for Brain Science & Brain-machine Integration, Zhejiang University, Hangzhou, 310027, China; State Key Laboratory of Transducer Technology, Chinese Academy of Sciences, Shanghai, 200050, China. Electronic address: thisiszlj@163.com. ^[5] Biosensor National Special Laboratory, Key Laboratory for Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou, 310027, China; The MOE Frontier Science Center for Brain Science & Brain-machine Integration, Zhejiang University, Hangzhou, 310027, China; State Key Laboratory of Transducer Technology, Chinese Academy of Sciences, Shanghai, 200050, China. Electronic address: cnpwang@zju.edu.cn. ^[6]

关键词 Alzheimer's disease Biomimetic sensor Microelectrode array Neuronal network-based chip Olfactory bulb Olfactory dysfunction