Simultaneous detection of cancerous exosomal miRNA-21 and PD-L1 with a sensitive dual-cycling nanoprobe.

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作者： Xiaoling,Qin ^[1] ; Yuanhang,Xiang ^[1] ; Na,Li ^[1] ; Binqi,Wei ^[1] ; Yu,Chen ^[1] ; Dan,Fang ^[1] ; Min,Fang ^[2] ; Qiaofeng,Li ^[1] ; Jia,Liu ^[3] ; Yujin,Tang ^[3] ; Xinchun,Li ^[1] ; Fan,Yang ^[4]

作者单位： Key Laboratory of Micro-Nanoscale Bioanalysis and Drug Screening of Guangxi Higher Education, Guangxi Beibu Gulf Marine Biomedicine Precision Development and High-Value Utilization Engineering Research Center, National Center for International Research of Bio-targeting Theranostics, School of Pharmacy, Guangxi Medical University, Nanning, 530021, China. ^[1] Department of Clinical Laboratory, The Affiliated Tumor Hospital of Guangxi Medical University, Nanning, 530021, China. ^[2] Guangxi Key Laboratory of Basic and Translational Research of Bone and Joint Degenerative Diseases, Department of Orthopedics, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, 533000, China. ^[3] Key Laboratory of Micro-Nanoscale Bioanalysis and Drug Screening of Guangxi Higher Education, Guangxi Beibu Gulf Marine Biomedicine Precision Development and High-Value Utilization Engineering Research Center, National Center for International Research of Bio-targeting Theranostics, School of Pharmacy, Guangxi Medical University, Nanning, 530021, China. Electronic address: yangfan@gxmu.edu.cn. ^[4]

关键词 DNA molecular Machine Dual-cycling nanoprobe Exosomal miRNA PD-L1 Simultaneous detection