Paradoxical activation of transcription factor SREBP1c and de novo lipogenesis by hepatocyte-selective ATP-citrate lyase depletion in obese mice.

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第一作者： Batuhan,Yenilmez

第一单位： Program in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA.

作者： Batuhan,Yenilmez ^[1] ; Mark,Kelly ^[1] ; Guo-Fang,Zhang ^[2] ; Nicole,Wetoska ^[1] ; Olga R,Ilkayeva ^[2] ; Kyounghee,Min ^[1] ; Leslie,Rowland ^[1] ; Chloe,DiMarzio ^[1] ; Wentao,He ^[2] ; Naideline,Raymond ^[1] ; Lawrence,Lifshitz ^[1] ; Meixia,Pan ^[3] ; Xianlin,Han ^[3] ; Jun,Xie ^[4] ; Randall H,Friedline ^[1] ; Jason K,Kim ^[1] ; Guangping,Gao ^[4] ; Mark A,Herman ^[2] ; Christopher B,Newgard ^[5] ; Michael P,Czech ^[6]

作者单位： Program in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA. ^[1] Sarah W. Stedman Nutrition and Metabolism Center and Duke Molecular Physiology Institute, Duke University Medical Center, Durham, North Carolina, USA; Department of Pharmacology and Cancer Biology, and Department of Medicine, Endocrinology and Metabolism Division, Duke University Medical Center, Durham, North Carolina, USA. ^[2] Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA. ^[3] Viral Vector Core, University of Massachusetts Medical School, Worcester, Massachusetts, USA. ^[4] Sarah W. Stedman Nutrition and Metabolism Center and Duke Molecular Physiology Institute, Duke University Medical Center, Durham, North Carolina, USA; Department of Pharmacology and Cancer Biology, and Department of Medicine, Endocrinology and Metabolism Division, Duke University Medical Center, Durham, North Carolina, USA. Electronic address: Chris.Newgard@duke.edu. ^[5] Program in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA. Electronic address: Michael.Czech@umassmed.edu. ^[6]

关键词 ACLY NAFLD de novo lipogenesis lipid metabolism liver metabolism metabolomics