Pharmacological targeting of microglia dynamics in Alzheimer's disease: Preclinical and clinical evidence.

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作者： Atrin,Yousefizadeh ^[1] ; Gaia,Piccioni ^[2] ; Amira,Saidi ^[2] ; Viviana,Triaca ^[3] ; Dalila,Mango ^[4] ; Robert,Nisticò ^[5]

作者单位： School of Pharmacy, Department of Biology, University of Rome "Tor Vergata", Rome, Italy. ^[1] Department of Physiology and Pharmacology "V.Erspamer", Sapienza University of Rome, Rome, Italy; Laboratory Pharmacology of Synaptic Plasticity, European Brain Research (EBRI) Institute, Rome, Italy. ^[2] Institute of Biochemistry and Cell Biology (IBBC), National Research Council (CNR), Rome, Italy. ^[3] School of Pharmacy, Department of Biology, University of Rome "Tor Vergata", Rome, Italy; Laboratory Pharmacology of Synaptic Plasticity, European Brain Research (EBRI) Institute, Rome, Italy. ^[4] School of Pharmacy, Department of Biology, University of Rome "Tor Vergata", Rome, Italy; Laboratory Pharmacology of Synaptic Plasticity, European Brain Research (EBRI) Institute, Rome, Italy. Electronic address: robert.nistico@uniroma2.it. ^[5]

关键词 Alzheimer’s disease Drug discovery Microglia Neuroinflammation Neuroprotection Synaptic plasticity

主题词阿尔茨海默病(Alzheimer Disease);淀粉样β肽类(Amyloid beta-Peptides);脑(Brain);人类(Humans);小神经胶质细胞(Microglia);神经元(Neurons);突触(Synapses)

DOI 10.1016/j.phrs.2022.106404

PMID 35988869

发布时间 2022-10-17

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