One-Pot Chemoenzymatic Synthesis of Microviridin Analogs Containing Functional Tags.

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作者： Stella,Scholz ^[1] ; Sofia,Kerestetzopoulou ^[1] ; Vincent,Wiebach ^[2] ; Romina,Schnegotzki ^[3] ; Bianca,Schmid ^[3] ; Emmanuel,Reyna-González ^[1] ; Ling,Ding ^[2] ; Roderich D,Süssmuth ^[3] ; Elke,Dittmann ^[1] ; Martin,Baunach ^[4]

作者单位： Department of Microbiology, University of Potsdam, Karl-Liebknecht-Str. 24/25, 14476, Potsdam-Golm, Germany. ^[1] Department of Biotechnology and Biomedicine, Technical University of Denmark, Søltofts Plads, Building 221, DK-2800 Kgs., Lyngby, Denmark. ^[2] Institute of Chemistry, Technical University Berlin, Straße des 17. Juni 124, 10623, Berlin, Germany. ^[3] Department of Microbiology, University of Potsdam, Karl-Liebknecht-Str. 24/25, 14476, Potsdam-Golm, Germany.;Institute of Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115, Bonn, Germany. ^[4]

关键词 RiPPs chemoenzymatic synthesis microviridins protease inhibitors synthetic biology

主题词肽类(Peptides);丝氨酸蛋白酶抑制剂(Serine Proteinase Inhibitors);蛋白质加工, 转译后(Protein Processing, Post-Translational);肽水解酶类(Peptide Hydrolases);内酰胺类(Lactams);内酯类(Lactones)

DOI 10.1002/cbic.202200345

PMID 35995730

发布时间 2024-09-10

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