首页> Frontiers of medicine> Palmitoylation of GNAQ/11 is critical for tumor cell proliferation and survival in GNAQ/11-mutant uveal melanoma.

Palmitoylation of GNAQ/11 is critical for tumor cell proliferation and survival in GNAQ/11-mutant uveal melanoma.

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第一作者： Yan,Zhang

第一单位： Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Collaborative Innovation Center of Hematology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.

作者： Yan,Zhang ^[1] ; Baoyuan,Zhang ^[1] ; Yongyun,Li ^[2] ; Yuting,Dai ^[1] ; Jiaoyang,Li ^[1] ; Donghe,Li ^[1] ; Zhizhou,Xia ^[1] ; Jianming,Zhang ^[1] ; Ping,Liu ^[1] ; Ming,Chen ^[1] ; Bo,Jiao ^[3] ; Ruibao,Ren ^[4]

作者单位： Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Collaborative Innovation Center of Hematology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. ^[1] Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, 200001, China. ^[2] Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Collaborative Innovation Center of Hematology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. bjiao@sibs.ac.cn. ^[3] Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Collaborative Innovation Center of Hematology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. ren@brandeis.edu.;Department of Biology, Brandeis University, Waltham, MA, 02454, USA. ren@brandeis.edu. ^[4]

关键词 BCL2 combination target therapy mutant GNAQ/11 palmitoylation uveal melanoma