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Barriers to the Intestinal Absorption of Four Insulin-Loaded Arginine-Rich Nanoparticles in Human and Rat.

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第一作者： Patrik,Lundquist

第一单位： Department of Pharmacy, Uppsala University, SE-751 43 Uppsala, Sweden.

作者： Patrik,Lundquist ^[1] ; Georgiy,Khodus ^[1] ; Zhigao,Niu ^[2] ; Lungile Nomcebo,Thwala ^[3] ; Fiona,McCartney ^[4] ; Ivailo,Simoff ^[1] ; Ellen,Andersson ^[5] ; Ana,Beloqui ^[6] ; Aloise,Mabondzo ^[7] ; Sandra,Robla ^[2] ; Dominic-Luc,Webb ^[8] ; Per M,Hellström ^[8] ; Åsa V,Keita ^[9] ; Eduardo,Sima ^[10] ; Noemi,Csaba ^[2] ; Magnus,Sundbom ^[10] ; Veronique,Preat ^[6] ; David J,Brayden ^[4] ; Maria Jose,Alonso ^[2] ; Per,Artursson ^[1]

作者单位： Department of Pharmacy, Uppsala University, SE-751 43 Uppsala, Sweden. ^[1] Department of Pharmacy and Pharmaceutical Technology, CIMUS, Universidade de Santiago de Compostela, Santiago de Compostela ES 15782, Spain. ^[2] Department of Pharmacy and Pharmaceutical Technology, CIMUS, Universidade de Santiago de Compostela, Santiago de Compostela ES 15782, Spain.;Université catholique de Louvain, UCLouvain, Louvain Drug Research Institute, Advanced Drug Delivery and Biomaterials, BE 1200 Brussels, Belgium. ^[3] UCD School of Veterinary Medicine, University College Dublin, Belfield D04 V1W8, Ireland. ^[4] Department of Surgery in Norrköping, Linköping University, SE-581 83 Norrköping, Sweden.;Department of Biomedical and Clinical Sciences, Linköping University, SE-581 83 Linköping, Sweden. ^[5] Université catholique de Louvain, UCLouvain, Louvain Drug Research Institute, Advanced Drug Delivery and Biomaterials, BE 1200 Brussels, Belgium. ^[6] CEA, Institute of Biology and Technology of Saclay, Department of Pharmacology and Immunoanalysis, Gif sur Yvette FR 91191, France. ^[7] Department of Medical Sciences, Uppsala University, SE-751 85 Uppsala, Sweden. ^[8] Department of Biomedical and Clinical Sciences, Linköping University, SE-581 83 Linköping, Sweden. ^[9] Department of Surgical Sciences-Upper Abdominal Surgery, Uppsala University, SE-751 85 Uppsala, Sweden. ^[10]

关键词 human insulin jejunum nanoparticle oral peptide delivery