首页> European journal of nuclear medicine and molecular imaging> Biodistribution and dosimetry in human healthy volunteers of the PET radioligands [11C]CHDI-00485180-R and [11C]CHDI-00485626, designed for quantification of cerebral aggregated mutant huntingtin.

Biodistribution and dosimetry in human healthy volunteers of the PET radioligands [11C]CHDI-00485180-R and [11C]CHDI-00485626, designed for quantification of cerebral aggregated mutant huntingtin.

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第一作者： Aline,Delva

第一单位： Department of Neurosciences, KU Leuven, Leuven, Belgium.;Department of Neurology, University Hospitals Leuven, Leuven, Belgium.

作者： Aline,Delva ^[1] ; Michel,Koole ^[2] ; Kim,Serdons ^[3] ; Guy,Bormans ^[4] ; Longbin,Liu ^[5] ; Jonathan,Bard ^[5] ; Vinod,Khetarpal ^[5] ; Celia,Dominguez ^[5] ; Ignacio,Munoz-Sanjuan ^[5] ; Andrew,Wood ^[5] ; Mette,Skinbjerg ^[5] ; Yuchuan,Wang ^[5] ; Wim,Vandenberghe ^[1] ; Koen,Van Laere ^[6]

作者单位： Department of Neurosciences, KU Leuven, Leuven, Belgium.;Department of Neurology, University Hospitals Leuven, Leuven, Belgium. ^[1] Nuclear Medicine and Molecular Imaging, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium. ^[2] Department of Radiopharmacy, University Hospitals Leuven, Leuven, Belgium. ^[3] Lab Radiopharmaceutical Research, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium. ^[4] CHDI Management/CHDI Foundation, Princeton, NJ, 08540, USA. ^[5] Nuclear Medicine and Molecular Imaging, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium. koen.vanlaere@uzleuven.be.;Division of Nuclear Medicine, University Hospitals Leuven, Leuven, België. koen.vanlaere@uzleuven.be. ^[6]

关键词 Biodistribution Dosimetry Huntingtine aggregates Huntington’s disease PET

医学主题词人类(Humans);成年人(Adult);组织分布(Tissue Distribution);放射测量术(Radiometry);正电子发射断层显像术(Positron-Emission Tomography)

DOI 10.1007/s00259-022-05945-z

PMID 36001116

发布时间 2024-12-23

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准确一般字义偏差语意偏离译文作用小提交