首页> Cancer communications (London, England)> PLEK2 promotes cancer stemness and tumorigenesis of head and neck squamous cell carcinoma via the c-Myc-mediated positive feedback loop.

PLEK2 promotes cancer stemness and tumorigenesis of head and neck squamous cell carcinoma via the c-Myc-mediated positive feedback loop.

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第一作者： Xinyuan,Zhao

第一单位： Department of Endodontics, Stomatological Hospital, Southern Medical University, Guangzhou, Guangdong, 510280, P. R. China.

作者： Xinyuan,Zhao ^[1] ; Dalong,Shu ^[2] ; Wenjuan,Sun ^[3] ; Shanshan,Si ^[4] ; Wei,Ran ^[2] ; Bing,Guo ^[5] ; Li,Cui ^[6]

作者单位： Department of Endodontics, Stomatological Hospital, Southern Medical University, Guangzhou, Guangdong, 510280, P. R. China. ^[1] Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510080, P. R. China. ^[2] Department of Stomatology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510630, P. R. China. ^[3] Department of Oral Emergency, Stomatological Hospital, Southern Medical University, Guangzhou, Guangdong, 510280, P. R. China. ^[4] Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510080, P. R. China.;Department of Dentistry, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510080, P. R. China. ^[5] Department of Oral and Maxillofacial Surgery, Stomatological Hospital, Southern Medical University, Guangzhou, Guangdong, 510280, P. R. China.;Division of Oral Biology and Medicine, School of Dentistry, University of California, Los Angeles, Los Angeles, California, 90095, United States. ^[6]

关键词 FBXW7 HNSCC PLEK2 c-Myc cancer stemness positive feedback loop tumorigenesis ubiquitination-mediated degradation