PD-L1<sup>+</sup> neutrophils as novel biomarkers for stage IV melanoma patients treated with nivolumab.

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作者： Leonardo,Cristinziano ^[1] ; Luca,Modestino ^[2] ; Mariaelena,Capone ^[3] ; Gabriele,Madonna ^[1] ; Domenico,Mallardo ^[2] ; Diana,Giannarelli ^[3] ; Grazia,D'Angelo ^[4] ; Anne Lise,Ferrara ^[4] ; Stefania,Loffredo ^[4] ; Gilda,Varricchi ^[5] ; Vito,Vanella ^[4] ; Lucia,Festino ^[1] ; Paolo Antonio,Ascierto ^[2] ; Maria Rosaria,Galdiero ^[3]

作者单位： Department of Translational Medical Sciences (DiSMeT), University of Naples Federico II, Naples, Italy. ^[1] Center for Basic and Clinical Immunology Research, Interdipartimental Center for basic and Clinical Immunology Research (CISI), University of Naples Federico II, Naples, Italy. ^[2] World Allergy Organization (WAO) Center of Excellence, University of Naples Federico II, Naples, Italy. ^[3] Melanoma, Cancer Immunotherapy, and Development Therapeutics Unit, Istituto Nazionale Tumori IRCCS Fondazione "G. Pascale", Naples, Italy. ^[4] Clinical Trial Center, Biostatistics and Bioinformatics Unit, Scientific Direction, Istituti di Ricovero e Cura a Carattere Scientifico (IRCCS) Regina Elena National Cancer Institute, Rome, Italy. ^[5] Institute of Experimental Endocrinology and Oncology, Istituto per l'Endocrinologia e l'Oncologia Sperimentale (IEOS), National Research Council (CNR), Naples, Italy. ^[6]

关键词 checkpoint inhibitors melanoma neutrophil plasticity nivolumab tumor-associated neutrophil

主题词人类(Humans);配体(Ligands);黑色素瘤(Melanoma);中性白细胞(Neutrophils);原癌基因蛋白质B-raf(Proto-Oncogene Proteins B-raf)

DOI 10.3389/fimmu.2022.962669

PMID 36016960

发布时间 2022-08-29

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