Personalized neoantigen vaccine NEO-PV-01 with chemotherapy and anti-PD-1 as first-line treatment for non-squamous non-small cell lung cancer.

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作者： Mark M,Awad ^[1] ; Ramaswamy,Govindan ^[2] ; Kristen N,Balogh ^[3] ; David R,Spigel ^[4] ; Edward B,Garon ^[5] ; Meghan E,Bushway ^[3] ; Asaf,Poran ^[3] ; Joong Hyuk,Sheen ^[3] ; Victoria,Kohler ^[3] ; Ekaterina,Esaulova ^[3] ; John,Srouji ^[3] ; Suchitra,Ramesh ^[3] ; Rohit,Vyasamneni ^[3] ; Binisha,Karki ^[5] ; Tracey E,Sciuto ^[3] ; Himanshu,Sethi ^[6] ; Jesse Z,Dong ^[3] ; Melissa A,Moles ^[3] ; Kelledy,Manson ^[3] ; Michael S,Rooney ^[3] ; Zakaria S,Khondker ^[3] ; Mark,DeMario ^[3] ; Richard B,Gaynor ^[7] ; Lakshmi,Srinivasan ^[8]

作者单位： Dana Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. ^[1] Washington University School of Medicine, St. Louis, MO, USA. ^[2] BioNTech US, Cambridge, MA, USA. ^[3] Tennessee Oncology, Nashville, TN, USA. ^[4] David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA. ^[5] Natera, Austin, TX, USA. ^[6] BioNTech US, Cambridge, MA, USA. Electronic address: richard.gaynor@biontech.us. ^[7] BioNTech US, Cambridge, MA, USA. Electronic address: lakshmi.srinivasan1@external.biontech.us. ^[8]

关键词 NEO-PV-01 cancer vaccine immunotherapy neoantigen vaccine non-small cell lung cancer

主题词抗原, 肿瘤(Antigens, Neoplasm);CD8阳性T淋巴细胞(CD8-Positive T-Lymphocytes);癌症疫苗(Cancer Vaccines);癌, 非小细胞肺(Carcinoma, Non-Small-Cell Lung);人类(Humans);免疫疗法(Immunotherapy);肺肿瘤(Lung Neoplasms)

DOI 10.1016/j.ccell.2022.08.003

PMID 36027916

发布时间 2022-09-21

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