Loss of ALK hotspot mutations in relapsed neuroblastoma.

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作者： Lisa M,Allinson ^[1] ; Aaron,Potts ^[2] ; Angharad,Goodman ^[2] ; Nick,Bown ^[2] ; Matthew,Bashton ^[3] ; Dean,Thompson ^[4] ; Nermine O,Basta ^[5] ; Alem S,Gabriel ^[1] ; Michael,McCorkindale ^[6] ; Antony,Ng ^[7] ; Richard J Q,McNally ^[5] ; Deborah A,Tweddle ^[1]

作者单位： Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Translational & Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK. ^[1] Newcastle Genetics Laboratory, Newcastle upon Tyne Hospitals NHS Trust, Newcastle upon Tyne, UK. ^[2] The Hub for Biotechnology in the Built Environment, Department of Applied Sciences, Faculty of Health and Life Sciences, Northumbria University, Newcastle upon Tyne, UK. ^[3] Department of Applied Sciences, Faculty of Health and Life Sciences, Northumbria University, Newcastle upon Tyne, UK. ^[4] Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK. ^[5] Bioinformatics Support Unit Newcastle University, Newcastle upon Tyne, UK. ^[6] Royal Hospital for Sick Children, Bristol, UK. ^[7] Great North Children's Hospital, Newcastle upon Tyne, UK. ^[8]

关键词 ALK loss mutation neuroblastoma relapse

主题词比较基因组杂交(Comparative Genomic Hybridization);人类(Humans);突变(Mutation);肿瘤复发, 局部(Neoplasm Recurrence, Local);神经母细胞瘤(Neuroblastoma);蛋白激酶抑制剂(Protein Kinase Inhibitors);受体蛋白质酪氨酸激酶类(Receptor Protein-Tyrosine Kinases)

DOI 10.1002/gcc.23093

PMID 36029175

发布时间 2023-01-10

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