Assessment of on-treatment platelet reactivity at high and low shear stress and platelet activation status after the addition of dipyridamole to aspirin in the early and late phases after TIA and ischaemic stroke.

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作者： S T,Lim ^[1] ; S J X,Murphy ^[2] ; S M,Murphy ^[3] ; T,Coughlan ^[4] ; D,O'Neill ^[4] ; S,Tierney ^[5] ; B,Egan ^[5] ; D R,Collins ^[4] ; A J,McCarthy ^[3] ; S-Y,Lim ^[6] ; D R,Smith ^[7] ; D,Cox ^[8] ; D J H,McCabe ^[9]

作者单位： Department of Neurology, Tallaght University Hospital/The Adelaide and Meath Hospital, Dublin, incorporating the National Children's Hospital (AMNCH), Dublin, Ireland; Stroke Service, Tallaght University Hospital/The Adelaide and Meath Hospital, Dublin, incorporating the National Children's Hospital (AMNCH), Dublin, Ireland; Department of Clinical Neurosciences, Royal Free Campus, UCL Queen Square Institute of Neurology, London, UK. ^[1] Department of Neurology, Tallaght University Hospital/The Adelaide and Meath Hospital, Dublin, incorporating the National Children's Hospital (AMNCH), Dublin, Ireland; Stroke Service, Tallaght University Hospital/The Adelaide and Meath Hospital, Dublin, incorporating the National Children's Hospital (AMNCH), Dublin, Ireland. ^[2] Department of Neurology, Tallaght University Hospital/The Adelaide and Meath Hospital, Dublin, incorporating the National Children's Hospital (AMNCH), Dublin, Ireland; Stroke Service, Tallaght University Hospital/The Adelaide and Meath Hospital, Dublin, incorporating the National Children's Hospital (AMNCH), Dublin, Ireland; Academic Unit of Neurology, School of Medicine, Trinity College Dublin, Dublin, Ireland. ^[3] Stroke Service, Tallaght University Hospital/The Adelaide and Meath Hospital, Dublin, incorporating the National Children's Hospital (AMNCH), Dublin, Ireland; Age-Related Health Care Department, Tallaght University Hospital/The Adelaide and Meath Hospital, Dublin, incorporating the National Children's Hospital (AMNCH), Dublin, Ireland. ^[4] Department of Vascular Surgery, Tallaght University Hospital/The Adelaide and Meath Hospital, Dublin, incorporating the National Children's Hospital (AMNCH), Dublin, Ireland. ^[5] Faculty of Health and Medical Sciences, Taylor's University, Selangor Darul Ehsan, Malaysia. ^[6] Department of Neurology, Tallaght University Hospital/The Adelaide and Meath Hospital, Dublin, incorporating the National Children's Hospital (AMNCH), Dublin, Ireland; Vascular Neurology Research Foundation, c/o Department of Neurology, Tallaght University Hospital/AMNCH, Dublin, Ireland; Stroke Service, Tallaght University Hospital/The Adelaide and Meath Hospital, Dublin, incorporating the National Children's Hospital (AMNCH), Dublin, Ireland; Academic Unit of Neurology, School of Medicine, Trinity College Dublin, Dublin, Ireland. ^[7] School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland; Irish Centre for Vascular Biology, Dublin, Ireland. ^[8] Department of Neurology, Tallaght University Hospital/The Adelaide and Meath Hospital, Dublin, incorporating the National Children's Hospital (AMNCH), Dublin, Ireland; Vascular Neurology Research Foundation, c/o Department of Neurology, Tallaght University Hospital/AMNCH, Dublin, Ireland; Stroke Service, Tallaght University Hospital/The Adelaide and Meath Hospital, Dublin, incorporating the National Children's Hospital (AMNCH), Dublin, Ireland; Department of Clinical Neurosciences, Royal Free Campus, UCL Queen Square Institute of Neurology, London, UK; Irish Centre for Vascular Biology, Dublin, Ireland; Stroke Clinical Trials Network Ireland, Dublin, Ireland; Academic Unit of Neurology, School of Medicine, Trinity College Dublin, Dublin, Ireland. Electronic address: dominick.mccabe@tuh.ie. ^[9]

关键词 Antiplatelet therapy Dipyridamole-high on-treatment platelet reactivity (HTPR)Flow cytometry Ischaemic stroke Platelet function/reactivity Shear stress TIA