换一批Novel role of macrophage TXNIP-mediated CYLD-NRF2-OASL1 axis in stress-induced liver inflammation and cell death.
第一作者：
Yongqiang,Zhan
第一单位：
The Dumont-UCLA Transplant Center, Division of Liver and Pancreas Transplantation, Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.;Department of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China.
作者：
关键词
ALT, alanine aminotransferaseAPAF1, apoptotic peptidase activating factor 1ASK1, apoptosis signal-regulating kinase 1AST, aspartate aminotransferaseApoptosisBMM, bone marrow-derived macrophageCXCL-10, C-X-C motif chemokine ligand 10CYLD, cyclindromatosisChIP, chromatin immunoprecipitationDAMP, damage-associated molecular patternDUB, deubiquitinating enzymeER, endoplasmic reticulumES, embryonic stemG3BP1G3BP1, Ras GTPase-activating protein-binding protein 1GCLC, glutamate-cysteine ligase catalytic subunitGCLM, glutamate-cysteine ligase regulatory subunitIHC, immunohistochemistryINF-β, interferon-βIR, ischaemia/reperfusionIRF3IRF3, interferon regulatory factor 3IRF7, IFN-regulating transcription factor 7IRI, ischaemia/reperfusion injuryInnate immunityKO, knockoutLPS, lipopolysaccharideLiver inflammationLyz2, Lysozyme 2MCP-1, monocyte chemoattractant protein 1NOX2, NADPH oxidase 2NOX4, NADPH oxidase 4NQO1, NAD(P)H quinone dehydrogenase 1NRF2, nuclear factor (erythroid-derived 2)-like 2NS, non-specificNecroptosisOASL1, 2′,5′oligoadenylate synthetase-like 1PAMP, pathogen-derived molecular patternRIPK3, receptor-interacting serine/threonine-protein kinase 3ROS, reactive oxygen speciesSTINGSTING, stimulator of interferon genesTBK1, TANK-binding kinase 1TLR4, Toll-like receptor 4TNF-α, tumour necrosis factor-alphaTRX, thioredoxinTSS, transcription start sitesTXNIP, thioredoxin-interacting proteinTXNIPFL/FL, floxed TXNIPTXNIPM-KO, myeloid-specific TXNIP KOUTR, untranslated regionsALT, serum ALTsAST, serum ASTsiRNA, small interfering RNA
DOI
10.1016/j.jhepr.2022.100532
PMID
36035360
发布时间
2024-05-15
- 浏览1
JHEP reports
2022年4卷9期
100532页
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