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首页> Journal of affective disorders> Effects of spleen nerve denervation on depression-like phenotype, systemic inflammation, and abnormal composition of gut microbiota in mice after administration of lipopolysaccharide: A role of brain-spleen axis.

Effects of spleen nerve denervation on depression-like phenotype, systemic inflammation, and abnormal composition of gut microbiota in mice after administration of lipopolysaccharide: A role of brain-spleen axis.

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作者： Li,Ma ^[1] ; Jiancheng,Zhang ^[2] ; Yuko,Fujita ^[2] ; Hiroyo,Shinno-Hashimoto ^[3] ; Jiajing,Shan ^[2] ; Xiayun,Wan ^[2] ; Youge,Qu ^[2] ; Lijia,Chang ^[2] ; Xingming,Wang ^[2] ; Kenji,Hashimoto ^[4]

作者单位： Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba 260-8670, Japan; Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China. ^[1] Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba 260-8670, Japan. ^[2] Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba 260-8670, Japan; Department of Dermatology, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan. ^[3] Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba 260-8670, Japan. Electronic address: hashimoto@faculty.chiba-u.jp. ^[4]

关键词 Depression Gut microbiota Hippocampus Inflammation Microglia Spleen

主题词动物(Animals);消炎药(Anti-Inflammatory Agents);脑(Brain);钙(Calcium);细胞因子类(Cytokines);去神经支配(Denervation);抑郁(Depression);炎症(Inflammation);白细胞介素6(Interleukin-6);脂多糖类(Lipopolysaccharides);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);表型(Phenotype);脾(Spleen);脾大(Splenomegaly);肿瘤坏死因子α(Tumor Necrosis Factor-alpha)

DOI 10.1016/j.jad.2022.08.087

PMID 36037991

发布时间 2022-10-19

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Journal of affective disorders

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