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首页> The Journal of biological chemistry> Protein arginine methyltransferase 5 is essential for oncogene product EWSR1-ATF1-mediated gene transcription in clear cell sarcoma.

Protein arginine methyltransferase 5 is essential for oncogene product EWSR1-ATF1-mediated gene transcription in clear cell sarcoma.

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作者： Bingbing X,Li ^[1] ; Larry L,David ^[2] ; Lara E,Davis ^[3] ; Xiangshu,Xiao ^[4]

作者单位： Department of Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, USA; Knight Cancer Institute, Oregon Health & Science University, Portland, USA. Electronic address: lib@ohsu.edu. ^[1] Department of Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, USA; Knight Cancer Institute, Oregon Health & Science University, Portland, USA. ^[2] Knight Cancer Institute, Oregon Health & Science University, Portland, USA; Division of Hematology and Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, USA. ^[3] Department of Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, USA; Knight Cancer Institute, Oregon Health & Science University, Portland, USA. Electronic address: xiaoxi@ohsu.edu. ^[4]

关键词 EWSR1-ATF1 JNJ-64619178 PRMT5 clear cell sarcoma inhibitor transcription

主题词人类(Humans);转录激活因子1(Activating Transcription Factor 1);cAMP反应元件结合蛋白质(Cyclic AMP Response Element-Binding Protein);癌基因蛋白质类, 融合(Oncogene Proteins, Fusion);蛋白质精氨酸N-甲基转移酶(Protein-Arginine N-Methyltransferases);蛋白质类(Proteins);RNA结合蛋白质EWS(RNA-Binding Protein EWS);肉瘤, 透明细胞(Sarcoma, Clear Cell);软组织肿瘤(Soft Tissue Neoplasms);转录, 遗传(Transcription, Genetic);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic)

DOI 10.1016/j.jbc.2022.102434

PMID 36041632

发布时间 2024-05-16

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The Journal of biological chemistry

The Journal of biological chemistry

2022年298卷10期

102434页

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