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Sequencing of Ipilimumab Plus Nivolumab and Encorafenib Plus Binimetinib for Untreated <i>BRAF</i>-Mutated Metastatic Melanoma (SECOMBIT): A Randomized, Three-Arm, Open-Label Phase II Trial.

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第一作者: Paolo A,Ascierto
第一单位: Department of Melanoma, Cancer Immunotherapy and Development Therapeutics, I.N.T. IRCCS Fondazione "G. Pascale" Napoli, Naples, Italy.
作者单位: Department of Melanoma, Cancer Immunotherapy and Development Therapeutics, I.N.T. IRCCS Fondazione "G. Pascale" Napoli, Naples, Italy. [1] Department of Oncology and Haematology, Papa Giovanni XXIII Cancer Center Hospital, Bergamo, Italy. [2] University of Perugia, Perugia, Italy. [3] Biotherapy of Tumors Unit, Department of Experimental Oncology, European Institute of Oncology, IRCCS, Milan, Italy. [4] Immunotherapy and Cell Therapy Unit, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy. [5] Department of Soft Tissue/Bone Sarcoma and Melanoma, Maria Sklodowska Curie National Research Institute of Oncology, Warsaw, Poland. [6] Department of Medical Oncology 1, IRCCS Regina Elena National Cancer Institute, Rome, Italy. [7] Department of Medical Oncology, Hospital Clínic Barcelona, Barcelona, Spain. [8] Rare Tumors and Melanoma Unit, IRCCS Istituto dei Tumori "Giovanni Paolo II," Bari, Italy. [9] Oncology Unit, Foundation IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy. [10] First Department of Medicine, National and Kapodistrian University of Athens, Zografou, Greece. [11] Department of Dermatology, Medical University of Graz, Graz, Austria. [12] Department of Medical Sciences, Dermatologic Clinic, University of Turin, Turin, Italy. [13] Department of Oncology-Pathology, Karolinska Institutet and Karolinska University Hospital Solna, Stockholm, Sweden. [14] IRCCS Ospedale Policlinico San Martino, Skin Cancer Unit, Genova, Italy. [15] Division of Melanoma Sarcoma and Rare Tumors, IRCCS European Institute of Oncology, Milan, Italy. [16] Department of Interdisciplinary Medicine, Oncology Unit, University of Bari "Aldo Moro," Bari, Italy. [17] Unit of Melanoma Medical Oncology, Department of Medical Oncology and Hematology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy. [18] Department of Medical Oncology, University Hospital Dexeus, Barcelona, Spain. [19] Academic Hospital "Santa Maria della Misericordia," Udine, Italy. [20] Department of Clinical Medicine and Surgery, University of Naples "Federico II," Naples, Italy. [21] Department of Immunology and Oncology, Clínica Universidad de Navarra, Pamplona, Spain. [22] Immuno-Oncology &amp; Targeted Cancer Biotherapies, University of Sassari, Unit of Cancer Genetics, IRGB-CNR, Sassari, Italy. [23] Medical Oncology Unit, AORN San Pio Benevento, Benevento, Italy. [24] Regina Elena National Cancer Institute, IRCCS-Biostatistical Unit, Rome, Italy. [25] Department of Dermatology, University and University Hospital Zurich, Zurich, Switzerland. [26] Melanoma Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, Padova, Italy. [27]
DOI 10.1200/JCO.21.02961
PMID 36049147
发布时间 2023-05-28
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Journal of clinical oncology : official journal of the American Society of Clinical Oncology

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