Metagenomes of rectal swabs in larger, advanced stage cervical cancers have enhanced mucus degrading functionalities and distinct taxonomic structure.

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第一作者： Tatiana V,Karpinets

第一单位： Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

作者： Tatiana V,Karpinets ^[1] ; Xiaogang,Wu ^[1] ; Travis,Solley ^[2] ; Molly B,El Alam ^[2] ; Travis T,Sims ^[3] ; Kyoko,Yoshida-Court ^[2] ; Erica,Lynn ^[2] ; Mustapha,Ahmed-Kaddar ^[2] ; Greyson,Biegert ^[2] ; Jingyan,Yue ^[2] ; Xingzhi,Song ^[1] ; Huandong,Sun ^[1] ; Joseph F,Petrosino ^[4] ; Melissa P,Mezzari ^[4] ; Pablo,Okhuysen ^[5] ; Patricia J,Eifel ^[2] ; Anuja,Jhingran ^[2] ; Lilie L,Lin ^[2] ; Kathleen M,Schmeler ^[3] ; Lois,Ramondetta ^[3] ; Nadim,Ajami ^[6] ; Robert R,Jenq ^[1] ; Andrew,Futreal ^[6] ; Jianhua,Zhang ^[1] ; Ann H,Klopp ^[7] ; Lauren E,Colbert ^[8]

作者单位： Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. ^[1] Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. ^[2] Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. ^[3] Alkek Center for Metagenomics and Microbiome Research, Baylor College of Medicine, Houston, TX, USA. ^[4] Department of Infectious Diseases, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. ^[5] Program for Innovative Microbiome and Translational Research, Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. ^[6] Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. JZhang22@mdanderson.org. ^[7] Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. AKlopp@mdanderson.org. ^[8] Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. lcolbert@mdanderson.org. ^[9]

关键词 Bacteria Bacteroidales Cervical cancer Clostridiales Gut Metagenomics Mucus layer Tumor size

主题词女(雌)性(Female);人类(Humans);代谢网络和途径(Metabolic Networks and Pathways);宏基因组(Metagenome);黏液(Mucus);宫颈肿瘤(Uterine Cervical Neoplasms)

DOI 10.1186/s12885-022-09997-0

PMID 36050658

发布时间 2023-04-21

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准确一般字义偏差语意偏离译文作用小提交