Dissecting the dynamic transcriptional landscape of early T helper cell differentiation into Th1, Th2, and Th1/2 hybrid cells.

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第一作者： Philipp,Burt

第一单位： Systems Biology of Inflammation, German Rheumatism Research Center (DRFZ), a Leibniz Institute, Berlin, Germany.

作者： Philipp,Burt ^[1] ; Michael,Peine ^[2] ; Caroline,Peine ^[3] ; Zuzanna,Borek ^[4] ; Sebastian,Serve ^[3] ; Michael,Floßdorf ^[4] ; Ahmed N,Hegazy ^[1] ; Thomas,Höfer ^[5] ; Max,Löhning ^[6] ; Kevin,Thurley ^[1]

作者单位： Systems Biology of Inflammation, German Rheumatism Research Center (DRFZ), a Leibniz Institute, Berlin, Germany. ^[1] Institute for Theoretical Biology, Humboldt University, Berlin, Germany. ^[2] Pitzer Laboratory of Osteoarthritis Research, German Rheumatism Research Center (DRFZ), a Leibniz Institute, Berlin, Germany. ^[3] Department of Rheumatology and Clinical Immunology, Charité-Universitätsmedizin, Berlin, Germany. ^[4] Department of Gastroenterology, Infectious Diseases and Rheumatology, Charité-Universitätsmedizin, Berlin, Germany. ^[5] Inflammatory Mechanisms, German Rheumatism Research Center (DRFZ), a Leibniz Institute, Berlin, Germany. ^[6] Division of Theoretical Systems Biology, German Cancer Research Center (DKFZ), Heidelberg, Germany. ^[7] Berlin Institute of Health (BIH), Berlin, Germany. ^[8] Institute for Experimental Oncology, Biomathematics Division, University Hospital Bonn, Bonn, Germany. ^[9]

关键词 T helper cell cell differentiation lineage commitment regression analysis time-course transcriptomics

主题词细胞分化(Cell Differentiation);杂交细胞(Hybrid Cells);淋巴细胞活化(Lymphocyte Activation);Th1细胞(Th1 Cells);Th2细胞(Th2 Cells)

DOI 10.3389/fimmu.2022.928018

PMID 36052070

发布时间 2022-09-14

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