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Small-Molecule Inhibition of the Acyl-Lysine Reader ENL as a Strategy against Acute Myeloid Leukemia.

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作者单位: Department of Cancer Biology, University of Pennsylvania, Philadelphia, Pennsylvania. [1] Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. [2] Division of Pediatric Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania. [3] Department of the School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, Pennsylvania. [4] Tri-Institutional Therapeutics Discovery Institute, New York, New York. [5] Wistar Institute, Gene Expression and Regulation Program, Philadelphia, Pennsylvania. [6] Cell and Molecular Biology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Pennsylvania. [7] Department of Systems Biology, Beckman Research Institute, City of Hope, Duarte, California. [8] MOE Key Laboratory of Protein Sciences, Beijing Frontier Research Center for Biological Structure, School of Medicine, Tsinghua University, and Tsinghua-Peking Center for Life Sciences, Beijing, China. [9] Bridge Medicines, New York, New York. [10] Pharmaron Drug Discovery, Pharmaron UK, West Hill Innovation Park, Hertford Road, Hoddesdon, Hertfordshire, United Kingdom. [11] Department of Pharmacology, Weill Cornell Medical College, New York, New York. [12] Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. [13] Division of Hematology/Oncology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. [14] Department of Physiology and Biophysics, Weill Cornell Medical College, New York, New York. [15] Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. [16] Institute for Regenerative Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. [17]
DOI 10.1158/2159-8290.CD-21-1307
PMID 36053276
发布时间 2023-02-02
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