Small-Molecule Inhibition of the Acyl-Lysine Reader ENL as a Strategy against Acute Myeloid Leukemia.
作者:
Yiman,Liu [1]
;
Qinglan,Li [2]
;
Fatemeh,Alikarami [1]
;
Declan R,Barrett [2]
;
Leila,Mahdavi [3]
;
Hangpeng,Li [3]
;
Sylvia,Tang [3]
;
Tanweer A,Khan [1]
;
Mayako,Michino [2]
;
Connor,Hill [4]
;
Lele,Song [1]
;
Lu,Yang [2]
;
Yuanyuan,Li [5]
;
Sheela Pangeni,Pokharel [5]
;
Andrew W,Stamford [6]
;
Nigel,Liverton [7]
;
Louis M,Renzetti [1]
;
Simon,Taylor [2]
;
Gillian F,Watt [8]
;
Tammy,Ladduwahetty [9]
;
Stacia,Kargman [8]
;
Peter T,Meinke [5]
;
Michael A,Foley [5]
;
Junwei,Shi [10]
;
Haitao,Li [11]
;
Martin,Carroll [11]
;
Chun-Wei,Chen [11]
;
Alessandro,Gardini [5]
;
Ivan,Maillard [10]
;
David J,Huggins [5]
;
Kathrin M,Bernt [12]
;
Liling,Wan [5]
作者单位:
Department of Cancer Biology, University of Pennsylvania, Philadelphia, Pennsylvania.
[1]
Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
[2]
Division of Pediatric Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
[3]
Department of the School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, Pennsylvania.
[4]
Tri-Institutional Therapeutics Discovery Institute, New York, New York.
[5]
Wistar Institute, Gene Expression and Regulation Program, Philadelphia, Pennsylvania.
[6]
Cell and Molecular Biology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Pennsylvania.
[7]
Department of Systems Biology, Beckman Research Institute, City of Hope, Duarte, California.
[8]
MOE Key Laboratory of Protein Sciences, Beijing Frontier Research Center for Biological Structure, School of Medicine, Tsinghua University, and Tsinghua-Peking Center for Life Sciences, Beijing, China.
[9]
Bridge Medicines, New York, New York.
[10]
Pharmaron Drug Discovery, Pharmaron UK, West Hill Innovation Park, Hertford Road, Hoddesdon, Hertfordshire, United Kingdom.
[11]
Department of Pharmacology, Weill Cornell Medical College, New York, New York.
[12]
Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
[13]
Division of Hematology/Oncology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
[14]
Department of Physiology and Biophysics, Weill Cornell Medical College, New York, New York.
[15]
Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
[16]
Institute for Regenerative Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
[17]
主题词
人类(Humans);赖氨酸(Lysine);白血病, 髓样, 急性(Leukemia, Myeloid, Acute);组蛋白类(Histones);染色质(Chromatin);髓淋巴细胞性白血病蛋白质(Myeloid-Lymphoid Leukemia Protein)
DOI
10.1158/2159-8290.CD-21-1307
PMID
36053276
发布时间
2023-02-02
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Cancer discovery
Cancer discovery
2684-2709页
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