Modeling human multi-lineage heart field development with pluripotent stem cells.

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作者： Donghe,Yang ^[1] ; Juliana,Gomez-Garcia ^[2] ; Shunsuke,Funakoshi ^[3] ; Thinh,Tran ^[4] ; Ian,Fernandes ^[5] ; Gary D,Bader ^[6] ; Michael A,Laflamme ^[7] ; Gordon M,Keller ^[8]

作者单位： McEwen Stem Cell Institute, University Health Network, Toronto, ON M5G 1L7, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada. Electronic address: donghe.yang@mail.utoronto.ca. ^[1] McEwen Stem Cell Institute, University Health Network, Toronto, ON M5G 1L7, Canada; Department of Biomedical Engineering, University of Toronto, Toronto, ON M5S 1A8, Canada. ^[2] McEwen Stem Cell Institute, University Health Network, Toronto, ON M5G 1L7, Canada. ^[3] Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada; The Donnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada. ^[4] McEwen Stem Cell Institute, University Health Network, Toronto, ON M5G 1L7, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada. ^[5] Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada; The Donnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada. ^[6] McEwen Stem Cell Institute, University Health Network, Toronto, ON M5G 1L7, Canada; Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, ON M5S 1A8, Canada. ^[7] McEwen Stem Cell Institute, University Health Network, Toronto, ON M5G 1L7, Canada; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada. Electronic address: gordon.keller@uhnresearch.ca. ^[8]

关键词 cardiac mesoderm specification cardiomyocyte subtypes hPSC models human and mouse comparison human heart field development scRNA-seq