Engineering Novel 3D Models to Recreate High-Grade Osteosarcoma and its Immune and Extracellular Matrix Microenvironment.

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第一作者： Marina,Pierrevelcin

第一单位： UMR CNRS 7021, Laboratory of Biomaging and Pathologies, Faculté de Pharmacie, 74 route du Rhin, Illkirch, 67405, France.

作者： Marina,Pierrevelcin ^[1] ; Vincent,Flacher ^[2] ; Christopher G,Mueller ^[2] ; Romain,Vauchelles ^[1] ; Eric,Guerin ^[3] ; Benoît,Lhermitte ^[4] ; Erwan,Pencreach ^[3] ; Andreas,Reisch ^[1] ; Quentin,Muller ^[2] ; Layal,Doumard ^[2] ; Wacym,Boufenghour ^[2] ; Andrey S,Klymchenko ^[1] ; Sophie,Foppolo ^[1] ; Charlotte,Nazon ^[5] ; Noelle,Weingertner ^[4] ; Sophie,Martin ^[1] ; Claire,Briandet ^[6] ; Véronique,Laithier ^[7] ; Antonio,Di Marco ^[8] ; Laurent,Bund ^[9] ; Adeline,Obrecht ^[10] ; Pascal,Villa ^[10] ; Monique,Dontenwill ^[1] ; Natacha,Entz-Werlé ^[11]

作者单位： UMR CNRS 7021, Laboratory of Biomaging and Pathologies, Faculté de Pharmacie, 74 route du Rhin, Illkirch, 67405, France. ^[1] CNRS UPR3572, Laboratory I2CT - Immunology, Immunopathology and Therapeutic Chemistry, Strasbourg Drug Discovery and Development Institute (IMS), Institut de Biologie Moléculaire et Cellulaire, 2, Allée Konrad Roentgen, Strasbourg, 67084, France. ^[2] Department of Cancer Molecular Genetics, Laboratory of Biochemistry and Molecular Biology, University Hospital of Strasbourg, 1 avenue Molière, Strasbourg, 67098, France. ^[3] Pathology department, University Hospital of Strasbourg, 1 avenue Molière, Strasbourg, 67098, France. ^[4] Pediatric Onco-hematology unit, University Hospital of Strasbourg, 1 avenue Molière, Strasbourg, 67098, France. ^[5] Pediatric Onco-hematology unit, Hospital of "Le Bocage"- University Hospital of Dijon, 1 bd Jeanne d'Arc, Dijon, 21079, France. ^[6] Pediatric Onco-hematology unit, University Hospital of Besançon, 3, boulevard A. Fleming, Besançon, 25030, France. ^[7] Department of Orthopedic Surgery and Traumatology, University Hospital of Strasbourg, 1 avenue Molière, Strasbourg, 67098, France. ^[8] Department of Pediatric Surgery, University Hospital of Strasbourg, 1 avenue Molière, Strasbourg, 67098, France. ^[9] PCBIS Plate-forme de chimie biologique intégrative de Strasbourg, UMS 3286 CNRS, University of Strasbourg, Labex Medalis, 300 Bld Sébastien Brant, Illkirch, 67412, France. ^[10] UMR CNRS 7021, Laboratory of Biomaging and Pathologies, Faculté de Pharmacie, 74 route du Rhin, Illkirch, 67405, France.;Pediatric Onco-hematology unit, University Hospital of Strasbourg, 1 avenue Molière, Strasbourg, 67098, France. ^[11]

关键词 2D cultures bone scaffolds hypoxia macrophages osteosarcoma spheroids