Parkin Insufficiency Accentuates High-Fat Diet-Induced Cardiac Remodeling and Contractile Dysfunction Through VDAC1-Mediated Mitochondrial Ca<sup>2+</sup> Overload.
第一作者:
Ne N,Wu
作者:
关键词
AMCM, adult murine cardiomyocyteBP, blood pressureCa2+ overloadHFD, high-fat dietLFD, low-fat dietLV, left ventricularMCU, mitochondrial Ca2+ uniporterPA, palmitic acidParkinROS, reactive oxygen speciesTR90, time to 90 relengtheningVDAC, voltage-dependent anion channelVDAC1WT, wild-typehearthigh-fat dietmPTP, mitochondrial permeability transition poremitochondria
DOI
10.1016/j.jacbts.2022.03.007
PMID
36061337
发布时间
2024-09-03
- 浏览5

JACC. Basic to translational science
2022年7卷8期
779-796页
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