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Integrated process model for the prediction of biopharmaceutical manufacturing chromatography and adjustment steps.

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第一作者： Federico,Rischawy

第一单位： DSP Development, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riß, Germany; Karlsruhe Institute of Technology (KIT), Institute of Engineering in Life Sciences, Section IV: Biomolecular Separation Engineering, Karlsruhe, Germany. Electronic address: daniel_federico.rischawy@boehringer-ingelheim.com.

作者： Federico,Rischawy ^[1] ; Till,Briskot ^[2] ; Adrian,Schimek ^[2] ; Gang,Wang ^[2] ; David,Saleh ^[2] ; Simon,Kluters ^[2] ; Joey,Studts ^[2] ; Jürgen,Hubbuch ^[3]

作者单位： DSP Development, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riß, Germany; Karlsruhe Institute of Technology (KIT), Institute of Engineering in Life Sciences, Section IV: Biomolecular Separation Engineering, Karlsruhe, Germany. Electronic address: daniel_federico.rischawy@boehringer-ingelheim.com. ^[1] DSP Development, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riß, Germany. ^[2] Karlsruhe Institute of Technology (KIT), Institute of Engineering in Life Sciences, Section IV: Biomolecular Separation Engineering, Karlsruhe, Germany. Electronic address: juergen.hubbuch@kit.edu. ^[3]

关键词 Adjustment step modeling Colloidal particle adsorption model Connected downstream process units Mechanistic modeling Process variability

医学主题词吸附(Adsorption);生物制品(Biological Products);色谱法, 离子交换(Chromatography, Ion Exchange);蛋白质类(Proteins);琼脂糖(Sepharose)

DOI 10.1016/j.chroma.2022.463421

PMID 36063778

发布时间 2022-09-23

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