AICAR transformylase/IMP cyclohydrolase (ATIC) is essential for de novo purine biosynthesis and infection by Cryptococcus neoformans.

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第一作者： Maha S I,Wizrah

第一单位： Australian Infectious Diseases Research Centre, University of Queensland, St Lucia, Queensland, Australia; School of Chemistry & Molecular Biosciences, University of Queensland, St Lucia, Queensland, Australia.

作者： Maha S I,Wizrah ^[1] ; Sheena M H,Chua ^[1] ; Zhenyao,Luo ^[2] ; Mohammad K,Manik ^[3] ; Mengqi,Pan ^[3] ; Jessica M L,Whyte ^[1] ; Avril A B,Robertson ^[3] ; Ulrike,Kappler ^[1] ; Bostjan,Kobe ^[3] ; James A,Fraser ^[4]

作者单位： Australian Infectious Diseases Research Centre, University of Queensland, St Lucia, Queensland, Australia; School of Chemistry & Molecular Biosciences, University of Queensland, St Lucia, Queensland, Australia. ^[1] School of Chemistry & Molecular Biosciences, University of Queensland, St Lucia, Queensland, Australia; Institute for Molecular Bioscience, University of Queensland, St Lucia, Queensland, Australia. ^[2] Australian Infectious Diseases Research Centre, University of Queensland, St Lucia, Queensland, Australia; School of Chemistry & Molecular Biosciences, University of Queensland, St Lucia, Queensland, Australia; Institute for Molecular Bioscience, University of Queensland, St Lucia, Queensland, Australia. ^[3] Australian Infectious Diseases Research Centre, University of Queensland, St Lucia, Queensland, Australia; School of Chemistry & Molecular Biosciences, University of Queensland, St Lucia, Queensland, Australia. Electronic address: j.fraser1@uq.edu.au. ^[4]

关键词 Cryptococcus neoformans X-ray crystallography bifunctional enzyme enzyme kinetics fungi microbial pathogenesis molecular genetics nucleoside/nucleotide metabolism purine de novo biosynthesis