首页> BMC bioinformatics> DMRscaler: a scale-aware method to identify regions of differential DNA methylation spanning basepair to multi-megabase features.

DMRscaler: a scale-aware method to identify regions of differential DNA methylation spanning basepair to multi-megabase features.

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第一作者： Leroy,Bondhus

第一单位： Department of Human Genetics, David Geffen School of Medicine, UCLA, 615 Charles E. Young Drive South, Los Angeles, CA, 90095, USA.;Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA, 90095, USA.;Department of Computational Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA, 90095, USA.

作者： Leroy,Bondhus ^[1] ; Angela,Wei ^[2] ; Valerie A,Arboleda ^[3]

作者单位： Department of Human Genetics, David Geffen School of Medicine, UCLA, 615 Charles E. Young Drive South, Los Angeles, CA, 90095, USA.;Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA, 90095, USA.;Department of Computational Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA, 90095, USA. ^[1] Department of Human Genetics, David Geffen School of Medicine, UCLA, 615 Charles E. Young Drive South, Los Angeles, CA, 90095, USA.;Bioinformatics Interdepartmental PhD Program, David Geffen School of Medicine, UCLA, Los Angeles, CA, 90095, USA.;Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA, 90095, USA.;Department of Computational Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA, 90095, USA. ^[2] Department of Human Genetics, David Geffen School of Medicine, UCLA, 615 Charles E. Young Drive South, Los Angeles, CA, 90095, USA. varboleda@mednet.ucla.edu.;Bioinformatics Interdepartmental PhD Program, David Geffen School of Medicine, UCLA, Los Angeles, CA, 90095, USA. varboleda@mednet.ucla.edu.;Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA, 90095, USA. varboleda@mednet.ucla.edu.;Department of Computational Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA, 90095, USA. varboleda@mednet.ucla.edu.;Molecular Biology Institute, UCLA, Los Angeles, CA, 90095, USA. varboleda@mednet.ucla.edu.;Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA, 90095, USA. varboleda@mednet.ucla.edu. ^[3]

关键词 Arboleda-Tham syndrome Chromatin Epigenome Rare disease Scale, DNA methylation Sotos syndrome Weaver syndrome

医学主题词染色质(Chromatin);DNA甲基化(DNA Methylation);后成说, 遗传(Epigenesis, Genetic);表观基因组学(Epigenomics);基因组(Genome);人类(Humans)

DOI 10.1186/s12859-022-04899-1

PMID 36064314

发布时间 2026-04-18

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准确一般字义偏差语意偏离译文作用小提交