Immune checkpoint inhibitor-induced hepatitis injury: risk factors, outcomes, and impact on survival.

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第一作者： Abdul,Miah

第一单位： Division of Medical Oncology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, 1810 Cannon Drive, Suite 1240C, Columbus, OH, 43210, USA.

作者： Abdul,Miah ^[1] ; Gabriel,Tinoco ^[2] ; Songzhu,Zhao ^[3] ; Lai,Wei ^[3] ; Andrew,Johns ^[1] ; Sandip,Patel ^[1] ; Mingjia,Li ^[1] ; Madison,Grogan ^[1] ; Gabrielle,Lopez ^[1] ; Marium,Husain ^[1] ; Rebecca,Hoyd ^[1] ; Khalid,Mumtaz ^[4] ; Alexa,Meara ^[1] ; Erin M,Bertino ^[5] ; Kari,Kendra ^[1] ; Daniel,Spakowicz ^[1] ; Gregory A,Otterson ^[1] ; Carolyn J,Presley ^[1] ; Dwight H,Owen ^[1]

作者单位： Division of Medical Oncology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, 1810 Cannon Drive, Suite 1240C, Columbus, OH, 43210, USA. ^[1] Division of Medical Oncology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, 1810 Cannon Drive, Suite 1240C, Columbus, OH, 43210, USA. Gabriel.Tinoco@osumc.edu. ^[2] Department of Biomedical Informatics and Center for Biostatistics, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA. ^[3] Division of Gastroenterology Hepatology and Nutrition, The Ohio State University, Columbus, OH, USA. ^[4] Division of Rheumatology and Immunology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA. ^[5]

关键词 Hepatitis Hepatotoxicity Immune checkpoint inhibitor (ICI)Immune-related adverse event (irAE)Immunotherapy Liver injury

主题词人类(Humans);女(雌)性(Female);回顾性研究(Retrospective Studies);肿瘤(Neoplasms);肝炎(Hepatitis);危险因素(Risk Factors)

DOI 10.1007/s00432-022-04340-3

PMID 36070148

发布时间 2024-05-02

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