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Stabilized HIV-1 envelope immunization induces neutralizing antibodies to the CD4bs and protects macaques against mucosal infection.

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第一作者: Kevin O,Saunders
第一单位: Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710, USA.;Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA.;Department of Microbiology and Molecular Genetics, Duke University Medical Center, Durham, NC 27710, USA.;Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA.
作者单位: Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710, USA.;Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA.;Department of Microbiology and Molecular Genetics, Duke University Medical Center, Durham, NC 27710, USA.;Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA. [1] Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710, USA.;Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA. [2] Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710, USA.;Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA.;Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA. [3] Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710, USA.;Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA. [4] Beth Israel Deaconess Medical Center, Boston, MA 02215, USA. [5] 3M Corporate Research Materials Lab, 3M Company, St. Paul, MN 55144, USA. [6] Infectious Disease Research Institute, Seattle, WA 98102, USA. [7] Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710, USA.;Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA. [8] Bioqual Inc., Rockville, MD 20850-3220, USA. [9] Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. [10] Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710, USA.;Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA.;Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA. [11]
DOI 10.1126/scitranslmed.abo5598
PMID 36070369
发布时间 2024-01-10
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Science translational medicine

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