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The spindle assembly checkpoint is a therapeutic vulnerability of CDK4/6 inhibitor-resistant ER<sup>+</sup> breast cancer with mitotic aberrations.

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第一作者： Isabel,Soria-Bretones

第一单位： Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.;Segal Cancer Centre and Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC, Canada.;Gerald Bronfman Department of Oncology, McGill University, Montreal, QC, Canada.

作者： Isabel,Soria-Bretones ^[1] ; Kelsie L,Thu ^[2] ; Jennifer,Silvester ^[3] ; Jennifer,Cruickshank ^[3] ; Samah,El Ghamrasni ^[3] ; Wail,Ba-Alawi ^[3] ; Graham C,Fletcher ^[3] ; Reza,Kiarash ^[3] ; Mitchell J,Elliott ^[4] ; Jordan J,Chalmers ^[3] ; Andrea C,Elia ^[3] ; Albert,Cheng ^[3] ; April A N,Rose ^[5] ; Mark R,Bray ^[3] ; Benjamin,Haibe-Kains ^[3] ; Tak W,Mak ^[3] ; David W,Cescon ^[4]

作者单位： Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.;Segal Cancer Centre and Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC, Canada.;Gerald Bronfman Department of Oncology, McGill University, Montreal, QC, Canada. ^[1] Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.;Keenan Research Centre for Biomedical Sciences, St. Michael's Hospital , Toronto,, ON, Canada.;Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada. ^[2] Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada. ^[3] Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.;Department of Medicine, University of Toronto, Toronto , ON, Canada. ^[4] Segal Cancer Centre and Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC, Canada.;Gerald Bronfman Department of Oncology, McGill University, Montreal, QC, Canada. ^[5]

医学主题词细胞系, 肿瘤(Cell Line, Tumor);抗药性, 肿瘤(Drug Resistance, Neoplasm);肿瘤(Neoplasms)

DOI 10.1126/sciadv.abq4293

PMID 36070391

发布时间 2022-09-30

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The spindle assembly checkpoint is a therapeutic vulnerability of CDK4/6 inhibitor-resistant ER<sup>+</sup> breast cancer with mitotic aberrations.

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The spindle assembly checkpoint is a therapeutic vulnerability of CDK4/6 inhibitor-resistant ER<sup>+</sup> breast cancer with mitotic aberrations.

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