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Safety, Immunogenicity, and 1-Year Efficacy of Universal Cancer Peptide-Based Vaccine in Patients With Refractory Advanced Non-Small-Cell Lung Cancer: A Phase Ib/Phase IIa De-Escalation Study.

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第一作者: Olivier,Adotévi
第一单位: Department of Medical Oncology, University Hospital of Besançon, Besançon, France.;INSERM, EFS BFC, UMR1098, RIGHT, University of Bourgogne Franche-Comté, Besançon, France.
作者单位: Department of Medical Oncology, University Hospital of Besançon, Besançon, France.;INSERM, EFS BFC, UMR1098, RIGHT, University of Bourgogne Franche-Comté, Besançon, France. [1] INSERM, EFS BFC, UMR1098, RIGHT, University of Bourgogne Franche-Comté, Besançon, France.;Department of Medical Oncology, Methodology and Quality of Life Unit in Oncology, University Hospital of Besançon, Besançon, France. [2] Department of Pneumology, University Hospital of Besançon, Besançon, France. [3] Department of Medical Oncology, Methodology and Quality of Life Unit in Oncology, University Hospital of Besançon, Besançon, France. [4] INSERM, EFS BFC, UMR1098, RIGHT, University of Bourgogne Franche-Comté, Besançon, France.;EFS Bourgogne Franche-Comté, UMR1098, Plateforme de Biomonitoring, Besançon, France. [5] Department of Medical Oncology, University Hospital of Besançon, Besançon, France. [6] INSERM CIC-1431, Clinical Investigation Center in Biotherapy, University Hospital of Besançon, Besançon, France. [7] INSERM, EFS BFC, UMR1098, RIGHT, University of Bourgogne Franche-Comté, Besançon, France.;EFS Bourgogne Franche-Comté, UMR1098, Plateforme de Biomonitoring, Besançon, France.;INSERM CIC-1431, Clinical Investigation Center in Biotherapy, University Hospital of Besançon, Besançon, France. [8] INSERM, EFS BFC, UMR1098, RIGHT, University of Bourgogne Franche-Comté, Besançon, France. [9] Department of Medical Oncology, University Hospital of Besançon, Besançon, France.;Department of Pneumology, University Hospital of Besançon, Besançon, France. [10] INSERM, EFS BFC, UMR1098, RIGHT, University of Bourgogne Franche-Comté, Besançon, France.;Department of Pneumology, University Hospital of Besançon, Besançon, France. [11] Department of Medical Oncology, Georges François Leclerc Cancer Center-UNICANCER, Dijon, France. [12] Department of Medical Oncology, AP-HP Hôpital Saint Louis, Paris, France. [13] INSERM CIC 1427, Centre d'Investigations Cliniques, Université de Paris Cité, AP-HP Hôpital Saint-Louis, Paris, France. [14] Department of Pharmacy, University Hospital of Besançon, Besançon, France. [15] Hygiène Hospitalière, Centre Hospitalier Universitaire, Besançon, France. [16] Vigilance Unit, Department of Clinical Research and Innovation, University Hospital of Besançon, Besançon, France. [17] INSERM, EFS BFC, UMR1098, RIGHT, University of Bourgogne Franche-Comté, Besançon, France.;Department of Pharmacy, University Hospital of Besançon, Besançon, France. [18] Department of Pneumology, Strasbourg University Hospital, Strasbourg, France. [19] University of Strasbourg, Inserm UMR_S1113, IRFAC, Laboratory Streinth (Stress rEsponse and iNnovative therapy against cancer), ITI InnoVec, Strasbourg, France. [20] GHRMSA, Mulhouse, France. [21] Department of Medical Oncology, University Hospital of Besançon, Besançon, France.;INSERM, EFS BFC, UMR1098, RIGHT, University of Bourgogne Franche-Comté, Besançon, France.;INSERM CIC-1431, Clinical Investigation Center in Biotherapy, University Hospital of Besançon, Besançon, France. [22]
DOI 10.1200/JCO.22.00096
PMID 36070539
发布时间 2023-02-08
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Journal of clinical oncology : official journal of the American Society of Clinical Oncology

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