换一批Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention.
第一作者：
Zhe,Wang
第一单位：
The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. zhe.wang@mssm.edu.
作者：
Zhe,Wang [1]
;
Andrew,Emmerich [2]
;
Nicolas J,Pillon [3]
;
Tim,Moore [4]
;
Daiane,Hemerich [5]
;
Marilyn C,Cornelis [6]
;
Eugenia,Mazzaferro [7]
;
Siacia,Broos [8]
;
Tarunveer S,Ahluwalia [9]
;
Traci M,Bartz [10]
;
Amy R,Bentley [11]
;
Lawrence F,Bielak [12]
;
Mike,Chong [13]
;
Audrey Y,Chu [14]
;
Diane,Berry [15]
;
Rajkumar,Dorajoo [16]
;
Nicole D,Dueker [17]
;
Elisa,Kasbohm [18]
;
Bjarke,Feenstra [19]
;
Mary F,Feitosa [20]
;
Christian,Gieger [21]
;
Mariaelisa,Graff [22]
;
Leanne M,Hall [23]
;
Toomas,Haller [24]
;
Fernando P,Hartwig [25]
;
David A,Hillis [26]
;
Ville,Huikari [27]
;
Nancy,Heard-Costa [28]
;
Christina,Holzapfel [29]
;
Anne U,Jackson [30]
;
Åsa,Johansson [31]
;
Anja Moltke,Jørgensen [32]
;
Marika A,Kaakinen [33]
;
Robert,Karlsson [34]
;
Kathleen F,Kerr [35]
;
Boram,Kim [36]
;
Chantal M,Koolhaas [37]
;
Zoltan,Kutalik [38]
;
Vasiliki,Lagou [39]
;
Penelope A,Lind [40]
;
Mattias,Lorentzon [41]
;
Leo-Pekka,Lyytikäinen [42]
;
Massimo,Mangino [43]
;
Christoph,Metzendorf [7]
;
Kristine R,Monroe [44]
;
Alexander,Pacolet [45]
;
Louis,Pérusse [46]
;
Rene,Pool [47]
;
Rebecca C,Richmond [48]
;
Natalia V,Rivera [49]
;
Sebastien,Robiou-du-Pont [50]
;
Katharina E,Schraut [51]
;
Christina-Alexandra,Schulz [52]
;
Heather M,Stringham [30]
;
Toshiko,Tanaka [53]
;
Alexander,Teumer [54]
;
Constance,Turman [55]
;
Peter J,van der Most [56]
;
Mathias,Vanmunster [45]
;
Frank J A,van Rooij [37]
;
Jana V,van Vliet-Ostaptchouk [57]
;
Xiaoshuai,Zhang [58]
;
Jing-Hua,Zhao [59]
;
Wei,Zhao [12]
;
Zhanna,Balkhiyarova [60]
;
Marie N,Balslev-Harder [32]
;
Sebastian E,Baumeister [61]
;
John,Beilby [62]
;
John,Blangero [63]
;
Dorret I,Boomsma [47]
;
Soren,Brage [64]
;
Peter S,Braund [23]
;
Jennifer A,Brody [65]
;
Marcel,Bruinenberg [66]
;
Ulf,Ekelund [67]
;
Ching-Ti,Liu [68]
;
John W,Cole [69]
;
Francis S,Collins [70]
;
L Adrienne,Cupples [71]
;
Tõnu,Esko [24]
;
Stefan,Enroth [31]
;
Jessica D,Faul [72]
;
Lindsay,Fernandez-Rhodes [73]
;
Alison E,Fohner [74]
;
Oscar H,Franco [75]
;
Tessel E,Galesloot [76]
;
Scott D,Gordon [77]
;
Niels,Grarup [32]
;
Catharina A,Hartman [78]
;
Gerardo,Heiss [22]
;
Jennie,Hui [79]
;
Thomas,Illig [80]
;
Russell,Jago [81]
;
Alan,James [82]
;
Peter K,Joshi [83]
;
Taeyeong,Jung [36]
;
Mika,Kähönen [84]
;
Tuomas O,Kilpeläinen [32]
;
Woon-Puay,Koh [85]
;
Ivana,Kolcic [86]
;
Peter P,Kraft [55]
;
Johanna,Kuusisto [87]
;
Lenore J,Launer [88]
;
Aihua,Li [50]
;
Allan,Linneberg [89]
;
Jian'an,Luan [64]
;
Pedro Marques,Vidal [90]
;
Sarah E,Medland [91]
;
Yuri,Milaneschi [92]
;
Arden,Moscati [5]
;
Bill,Musk [93]
;
Christopher P,Nelson [23]
;
Ilja M,Nolte [56]
;
Nancy L,Pedersen [34]
;
Annette,Peters [94]
;
Patricia A,Peyser [12]
;
Christine,Power [15]
;
Olli T,Raitakari [95]
;
Mägi,Reedik [24]
;
Alex P,Reiner [96]
;
Paul M,Ridker [97]
;
Igor,Rudan [51]
;
Kathy,Ryan [98]
;
Mark A,Sarzynski [99]
;
Laura J,Scott [30]
;
Robert A,Scott [64]
;
Stephen,Sidney [100]
;
Kristin,Siggeirsdottir [101]
;
Albert V,Smith [102]
;
Jennifer A,Smith [103]
;
Emily,Sonestedt [104]
;
Marin,Strøm [105]
;
E Shyong,Tai [106]
;
Koon K,Teo [107]
;
Barbara,Thorand [94]
;
Anke,Tönjes [108]
;
Angelo,Tremblay [46]
;
Andre G,Uitterlinden [109]
;
Jagadish,Vangipurapu [87]
;
Natasja,van Schoor [110]
;
Uwe,Völker [111]
;
Gonneke,Willemsen [47]
;
Kayleen,Williams [35]
;
Quenna,Wong [35]
;
Huichun,Xu [98]
;
Kristin L,Young [22]
;
Jian Min,Yuan [112]
;
M Carola,Zillikens [109]
;
Alan B,Zonderman [113]
;
Adam,Ameur [31]
;
Stefania,Bandinelli [114]
;
Joshua C,Bis [65]
;
Michael,Boehnke [30]
;
Claude,Bouchard [115]
;
Daniel I,Chasman [97]
;
George Davey,Smith [116]
;
Eco J C,de Geus [47]
;
Louise,Deldicque [117]
;
Marcus,Dörr [118]
;
Michele K,Evans [113]
;
Luigi,Ferrucci [53]
;
Myriam,Fornage [119]
;
Caroline,Fox [120]
;
Theodore,Garland [121]
;
Vilmundur,Gudnason [122]
;
Ulf,Gyllensten [31]
;
Torben,Hansen [32]
;
Caroline,Hayward [123]
;
Bernardo L,Horta [124]
;
Elina,Hyppönen [125]
;
Marjo-Riitta,Jarvelin [126]
;
W Craig,Johnson [35]
;
Sharon L R,Kardia [12]
;
Lambertus A,Kiemeney [76]
;
Markku,Laakso [87]
;
Claudia,Langenberg [127]
;
Terho,Lehtimäki [42]
;
Loic Le,Marchand [128]
;
Lifelines Cohort Study [34]
;
Patrik K E,Magnusson [77]
;
Nicholas G,Martin [129]
;
Mads,Melbye [24]
;
Andres,Metspalu [130]
;
David,Meyre [22]
;
Kari E,North [131]
;
Claes,Ohlsson [78]
;
Albertine J,Oldehinkel [104]
;
Marju,Orho-Melander [13]
;
Guillaume,Pare [132]
;
Taesung,Park [32]
;
Oluf,Pedersen [92]
;
Brenda W J H,Penninx [32]
;
Tune H,Pers [133]
;
Ozren,Polasek [134]
;
Inga,Prokopenko [11]
;
Charles N,Rotimi [23]
;
Nilesh J,Samani [135]
;
Xueling,Sim [56]
;
Harold,Snieder [136]
;
Thorkild I A,Sørensen [137]
;
Tim D,Spector [138]
;
Nicholas J,Timpson [139]
;
Rob M,van Dam [140]
;
Nathalie,van der Velde [141]
;
Cornelia M,van Duijn [90]
;
Peter,Vollenweider [54]
;
Henry,Völzke [37]
;
Trudy,Voortman [90]
;
Gérard,Waeber [64]
;
Nicholas J,Wareham [72]
;
David R,Weir [94]
;
Heinz-Erich,Wichmann [142]
;
James F,Wilson [143]
;
Andrea L,Hevener [3]
;
Anna,Krook [144]
;
Juleen R,Zierath [145]
;
Martine A I,Thomis [146]
;
Ruth J F,Loos [147]
;
Marcel den,Hoed
作者单位：
The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. zhe.wang@mssm.edu.
[1]
Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden.
[2]
Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
[3]
Division of Cardiology, Department of Medicine, University of California, Los Angeles, CA, USA.
[4]
The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
[5]
Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
[6]
The Beijer Laboratory and Department of Immunology, Genetics and Pathology, Uppsala University and SciLifeLab, Uppsala, Sweden.
[7]
Faculty of Movement and Rehabilitation Sciences, Department of Movement Sciences - Exercise Physiology Research Group, KU Leuven, Leuven, Belgium.;Faculty of Movement and Rehabilitation Sciences, Department of Movement Sciences - Physical Activity, Sports & Health Research Group, KU Leuven, Leuven, Belgium.
[8]
Steno Diabetes Center Copenhagen, Herlev, Denmark.;Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.;The Bioinformatics Center, Department of Biology, University of Copenhagen, Copenhagen, Denmark.
[9]
Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.;Department of Biostatistics, University of Washington, Seattle, WA, USA.
[10]
Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
[11]
Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
[12]
Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.
[13]
Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.;GlaxoSmithKline, Cambridge, MA, USA.
[14]
Division of Population, Policy and Practice, Great Ormond Street Hospital Institute for Child Health, University College London, London, UK.
[15]
Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore.;Health Services and Systems Research, Duke-NUS Medical School, Singapore, Singapore.
[16]
John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA.;Department of Epidemiology & Public Health, University of Maryland School of Medicine, Baltimore, MD, USA.
[17]
Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.;Institute of Mathematics and Computer Science, University of Greifswald, Greifswald, Germany.
[18]
Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
[19]
Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
[20]
Research Unit of Molecular Epidemiology, Helmholtz Zentrum München -Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH), Munich, Germany.
[21]
Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA.
[22]
Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.;NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.
[23]
Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
[24]
Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil.;MRC Integrative Epidemiology Unit, NIHR Bristol Biomedical Research Center, University of Bristol, Bristol, UK.
[25]
Genetics, Genomics, and Bioinformatics Graduate Program, University of California, Riverside, CA, USA.
[26]
Institute of Health Sciences, University of Oulu, Oulu, Finland.
[27]
Framingham Heart Study, Framingham, MA, USA.;Department of Neurology, Boston University School of Medicine, Boston, MA, USA.
[28]
Research Unit of Molecular Epidemiology, Helmholtz Zentrum München -Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH), Munich, Germany.;Institute for Nutritional Medicine, School of Medicine, Technical University of Munich, Munich, Germany.
[29]
Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
[30]
Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
[31]
Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
[32]
Section of Statistical Multi-omics, Department of Clinical and Experimental Medicine, University of Surrey, Guildford, UK.;Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.
[33]
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
[34]
Department of Biostatistics, University of Washington, Seattle, WA, USA.
[35]
Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul, South Korea.
[36]
Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
[37]
University Center for Primary Care and Public Health, University of Lausanne, Lausanne, Switzerland.;Swiss Institute of Bioinformatics, Lausanne, Switzerland.;Department of Computational Biology, University of Lausanne, Lausanne, Switzerland.
[38]
Wellcome Sanger Institute, Cambridge, UK.
[39]
Mental Health and Neuroscience Research Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.;School of Biomedical Science, Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia.
[40]
Geriatric Medicine, Institute of Medicine, University of Gothenburg and Sahlgrenska University Hospital Mölndal, Gothenburg, Sweden.;Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, Victoria, Australia.
[41]
Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.;Finnish Cardiovascular Research Center - Tampere, Department of Clinical Chemistry, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
[42]
Department of Twin Research and Genetic Epidemiology, Kings College London, London, UK.;NIHR Biomedical Research Centre at Guy's and St Thomas' Foundation Trust, London, UK.
[43]
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
[44]
Faculty of Movement and Rehabilitation Sciences, Department of Movement Sciences - Exercise Physiology Research Group, KU Leuven, Leuven, Belgium.
[45]
Department of Kinesiology, Université Laval, Quebec, Quebec, Canada.;Centre Nutrition Santé et Société (NUTRISS), Institute of Nutrition and Functional Foods (INAF), Université Laval, Quebec, Quebec, Canada.
[46]
Department of Biological Psychology, Vrije Universiteit, Amsterdam, the Netherlands.;Amsterdam Public Health Research Institute, Amsterdam UMC, Amsterdam, the Netherlands.
[47]
MRC Integrative Epidemiology Unit and Avon Longitudinal Study of Parents and Children, University of Bristol Medical School, Population Health Sciences and Avon Longitudinal Study of Parents and Children, University of Bristol, Bristol, UK.
[48]
Respiratory Division, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.;Rheumatology Division, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.;Center of Molecular Medicine (CMM), Karolinska Institutet, Stockholm, Sweden.
[49]
Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada.
[50]
Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK.
[51]
Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden.;Department of Nutrition and Food Sciences, Nutritional Epidemiology, University of Bonn, Bonn, Germany.
[52]
Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA.
[53]
Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.;German Centre for Cardiovascular Research (DZHK), partner site Greifswald, Greifswald, Germany.
[54]
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
[55]
Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
[56]
Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.;Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
[57]
MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.;School of Public Health, Department of Biostatistics, Shandong University, Jinan, China.
[58]
Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
[59]
Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.;Department of Clinical and Experimental Medicine, University of Surrey, Guilford, UK.;People-Centred Artificial Intelligence Institute, University of Surrey, Guilford, UK.
[60]
Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.;University of Münster, Münster, Germany.
[61]
Diagnostic Genomics, PathWest Laboratory Medicine WA, Perth, Western Australia, Australia.
[62]
South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, Brownsville, TX, USA.
[63]
MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
[64]
Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
[65]
Lifelines Cohort Study, Groningen, the Netherlands.
[66]
Department of Sports Medicine, Norwegian School of Sport Sciences, Oslo, Norway.;Department of Chronic Diseases, Norwegian Institute of Public Health, Oslo, Norway.
[67]
Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
[68]
Vascular Neurology, Department of Neurology, University of Maryland School of Medicine and the Baltimore VAMC, Baltimore, MD, USA.
[69]
Center for Precision Health Research, National Human Genome Research Institute, NIH, Bethesda, MD, USA.
[70]
Framingham Heart Study, Framingham, MA, USA.;Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
[71]
Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
[72]
Department of Biobehavioral Health, College of Health and Human Development, Pennsylvania State University, University Park, PA, USA.
[73]
Department of Epidemiology, Institute of Public Health Genetics, Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.
[74]
Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.;Institute of Social and Preventive Medicine (ISPM), University of Bern, Bern, Switzerland.
[75]
Radboud Institute for Health Sciences, Department for Health Evidence, Radboud University Medical Center, Nijmegen, the Netherlands.
[76]
Mental Health and Neuroscience Research Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
[77]
Interdisciplinary Center Psychopathology and Emotion Regulation, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
[78]
Diagnostic Genomics, PathWest Laboratory Medicine WA, Perth, Western Australia, Australia.;School of Population and Global Health, The University of Western Australia, Perth, Western Australia, Australia.;Busselton Population Medical Research Institute, Busselton, Western Australia, Australia.
[79]
Hannover Unified Biobank, Hannover Medical School, Hannover, Germany.;Department of Human Genetics, Hannover Medical School, Hannover, Germany.
[80]
Centre for Exercise Nutrition & Health Sciences, School for Policy Studies, University of Bristol, Bristol, UK.
[81]
Department of Pulmonary Physiology and Sleep Medicine, Sir Charles Gairdner Hospital, Western Australia, Perth, Australia.
[82]
Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK.;Humanity Inc, Boston, MA, USA.
[83]
Finnish Cardiovascular Research Center - Tampere, Department of Clinical Chemistry, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.;Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland.
[84]
Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.;Singapore Institute for Clinical Sciences, Agency for Science, Technology, and Research, Singapore, Singapore.
[85]
Department of Public Health, University of Split School of Medicine, Split, Croatia.
[86]
Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.
[87]
Laboratory of Epidemiology and Population Sciences, National Institutes of Health, Baltimore, MD, USA.
[88]
Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark.;Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
[89]
Division of Internal Medicine, Department of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
[90]
Mental Health and Neuroscience Research Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.;School of Psychology and Faculty of Medicine, University of Queensland, St Lucia, Queensland, Australia.
[91]
Department of Psychiatry, Amsterdam UMC, Vrije Universiteit, Amsterdam, the Netherlands.
[92]
Busselton Population Medical Research Institute, Busselton, Western Australia, Australia.
[93]
Institute of Epidemiology, Helmholtz Zentrum München -Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH), Munich, Germany.
[94]
Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.;Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.;Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.
[95]
Department of Epidemiology, University of Washington, Seattle, WA, USA.
[96]
Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.;Harvard Medical School, Boston, MA, USA.
[97]
Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
[98]
Department of Exercise Science, University of South Carolina, Columbia, SC, USA.
[99]
Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA.
[100]
Icelandic Heart Association, Kópavogur, Iceland.
[101]
Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.;Icelandic Heart Association, Kópavogur, Iceland.
[102]
Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.;Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
[103]
Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden.
[104]
Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.;Faculty of Health Sciences, University of the Faroe Islands, Tórshavn, Faroe Islands.
[105]
Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.;Duke-NUS Medical School, Singapore, Singapore.;Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
[106]
Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada.;Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
[107]
Department of Medicine, University of Leipzig, Leipzig, Germany.
[108]
Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands.
[109]
Department of Epidemiology and Biostatistics, Amsterdam Public Health Research Institute, VU University Medical Center, Amsterdam, the Netherlands.
[110]
German Centre for Cardiovascular Research (DZHK), partner site Greifswald, Greifswald, Germany.;Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.
[111]
Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.;Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
[112]
Laboratory of Epidemiology and Population Science, National Instiute on Aging, National Institutes of Health, Bethesda, MD, USA.
[113]
Geriatric Unit, Azienda USL Toscana Centro, Florence, Italy.
[114]
Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA.
[115]
MRC Integrative Epidemiology Unit, NIHR Bristol Biomedical Research Center, University of Bristol, Bristol, UK.;Population Health Science, Bristol Medical School, NIHR Bristol Biomedical Research Center, University of Bristol, Bristol, UK.
[116]
Faculty of Movement and Rehabilitation Sciences, Institute of Neuroscience, UC Louvain, Louvain-la-Neuve, Belgium.
[117]
German Centre for Cardiovascular Research (DZHK), partner site Greifswald, Greifswald, Germany.;Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany.
[118]
Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, TX, USA.
[119]
Genetics and Pharmacogenomics (GpGx), Merck Research Labs, Boston, MA, USA.
[120]
Department of Evolution, Ecology, and Organismal Biology, University of California, Riverside, Riverside, CA, USA.
[121]
Icelandic Heart Association, Kópavogur, Iceland.;Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
[122]
MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
[123]
Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil.
[124]
Australian Centre for Precision Health, Unit of Clinical and Health Sciences, University of South Australia, Adelaide, South Australia, Australia.;South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.;Population, Policy and Practice, Great Ormond Street Hospital Institute for Child Health, University College London, London, UK.
[125]
Institute of Health Sciences, University of Oulu, Oulu, Finland.;Department of Epidemiology and Biostatistics and HPA-MRC Center, School of Public Health, Imperial College London, London, UK.
[126]
MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.;Computational Medicine, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany.
[127]
Epidemiology Program, University of Hawaii Cancer Center, University of Hawaii at Manoa, Honolulu, HI, USA.
[128]
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.;K.G.Jebsen Center for Genetic Epidemiology, Norwegian University of Science and Technology, Trondheim, Norway.;Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.;Center for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.
[129]
Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.;Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada.
[130]
Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.;Department of Drug Treatment, Sahlgrenska University Hospital, Gothenburg, Sweden.
[131]
Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul, South Korea.;Department of Statistics, Seoul National University, Seoul, South Korea.
[132]
University of Split School of Medicine, Split, Croatia.
[133]
Department of Clinical and Experimental Medicine, University of Surrey, Guilford, UK.;People-Centred Artificial Intelligence Institute, University of Surrey, Guilford, UK.;UMR 8199 - EGID, Institut Pasteur de Lille, CNRS, University of Lille, Lille, France.
[134]
Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.
[135]
Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.;Department of Public Health, Section of Epidemiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
[136]
Department of Twin Research and Genetic Epidemiology, Kings College London, London, UK.
[137]
MRC Integrative Epidemiology Unit, University of Bristol Medical School, University of Bristol, Bristol, UK.
[138]
Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.;Department of Exercise and Nutrition Sciences, Milken Institute School of Public Health, George Washington University, Washington, DC, USA.
[139]
Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands.;Section of Geriatrics, Department of Internal Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.;Amsterdam Public Health, Aging and Later Life, Amsterdam, the Netherlands.
[140]
Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.;Nuffield Department of Population Health, University of Oxford, Oxford, UK.
[141]
Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK.;MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
[142]
Division of Endocrinology, Department of Medicine, University of California, Los Angeles, CA, USA.
[143]
Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.;Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.;Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
[144]
Faculty of Movement and Rehabilitation Sciences, Department of Movement Sciences - Physical Activity, Sports & Health Research Group, KU Leuven, Leuven, Belgium.
[145]
The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.;Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.;The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
[146]
The Beijer Laboratory and Department of Immunology, Genetics and Pathology, Uppsala University and SciLifeLab, Uppsala, Sweden. marcel.den_hoed@igp.uu.se.
[147]
医学主题词
辅肌动蛋白(Actinin);横断面研究(Cross-Sectional Studies);运动(Exercise)(Exercise);全基因组关联研究(Genome-Wide Association Study);人类(Humans);闲暇活动(Leisure Activities)
DOI
10.1038/s41588-022-01165-1
PMID
36071172
发布时间
2026-03-07
- 浏览1
Nature genetics
Nature genetics
1332-1344页
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