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Characterization of passive permeability after low intensity focused ultrasound mediated blood-brain barrier disruption in a preclinical model.

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第一作者： Tasneem A,Arsiwala

第一单位： Department of Pharmaceutical Sciences, School of Pharmacy, West Virginia University, HSC, Morgantown, 1 Medical Center Dr, Morgantown, WV, 26506, USA.

作者： Tasneem A,Arsiwala ^[1] ; Samuel A,Sprowls ^[2] ; Kathryn E,Blethen ^[1] ; Ross A,Fladeland ^[1] ; Cullen P,Wolford ^[1] ; Brooke N,Kielkowski ^[1] ; Morgan J,Glass ^[1] ; Peng,Wang ^[3] ; Olivia,Wilson ^[3] ; Jeffrey S,Carpenter ^[4] ; Manish,Ranjan ^[4] ; Victor,Finomore ^[5] ; Ali,Rezai ^[4] ; Paul R,Lockman ^[6]

作者单位： Department of Pharmaceutical Sciences, School of Pharmacy, West Virginia University, HSC, Morgantown, 1 Medical Center Dr, Morgantown, WV, 26506, USA. ^[1] Department of Pharmaceutical Sciences, School of Pharmacy, West Virginia University, HSC, Morgantown, 1 Medical Center Dr, Morgantown, WV, 26506, USA.;Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, 44106, USA. ^[2] Rockefeller Neuroscience Institute, West Virginia University, 1 Medical Center Dr, Morgantown, WV, 26505, USA. ^[3] Rockefeller Neuroscience Institute, West Virginia University, 1 Medical Center Dr, Morgantown, WV, 26505, USA.;Departments of Neuroscience, Neuroradiology, and Neurosurgery, West Virginia University, 1 Medical Center Dr, Morgantown, WV, 26505, USA. ^[4] Departments of Neuroscience, Neuroradiology, and Neurosurgery, West Virginia University, 1 Medical Center Dr, Morgantown, WV, 26505, USA. ^[5] Department of Pharmaceutical Sciences, School of Pharmacy, West Virginia University, HSC, Morgantown, 1 Medical Center Dr, Morgantown, WV, 26506, USA. prlockman@hsc.wvu.edu.;Departments of Neuroscience, Neuroradiology, and Neurosurgery, West Virginia University, 1 Medical Center Dr, Morgantown, WV, 26505, USA. prlockman@hsc.wvu.edu. ^[6]

关键词 Blood–Brain barrier Disruption ExAblate Neuro Focused ultrasound