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Resveratrol inhibits development of colorectal adenoma via suppression of LEF1; comprehensive analysis with connectivity map.

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第一作者： Hironori,Wada

第一单位： Department of Gastroenterology and Oncology, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan.

作者： Hironori,Wada ^[1] ; Yasushi,Sato ^[2] ; Shota,Fujimoto ^[1] ; Koichi,Okamoto ^[1] ; Masahiro,Bando ^[1] ; Tomoyuki,Kawaguchi ^[1] ; Hiroshi,Miyamoto ^[1] ; Naoki,Muguruma ^[1] ; Katsuhisa,Horimoto ^[3] ; Yui,Matsuzawa ^[4] ; Michihiro,Mutoh ^[5] ; Tetsuji,Takayama ^[1]

作者单位： Department of Gastroenterology and Oncology, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan. ^[1] Department of Community Medicine for Gastroenterology and Oncology, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan. ^[2] Molecular Profiling Research Center for Drug Discovery, National Institute of Advanced Industrial Science and Technology (AIST), Tokyo, Japan.;SOCIUM Inc, Tokyo, Japan. ^[3] Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan. ^[4] Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan.;Department of Molecular-Targeting Cancer Prevention, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan. ^[5]

关键词 LEF1 chemoprevention colorectal adenoma connectivity map resveratrol

医学主题词小鼠(Mice);大鼠(Rats);动物(Animals);腺瘤(Adenoma);结直肠肿瘤(Colorectal Neoplasms);化学预防(Chemoprevention);淋巴样增强子结合因子1(Lymphoid Enhancer-Binding Factor 1)

DOI 10.1111/cas.15576

PMID 36082704

发布时间 2022-12-21

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