Development of a novel high-throughput screen for the identification of new inhibitors of protein S-acylation.

导出 OA

翻译打印收藏纠错

作者： Christine,Salaun ^[1] ; Hiroya,Takizawa ^[2] ; Alex,Galindo ^[3] ; Kevin R,Munro ^[3] ; Jayde,McLellan ^[3] ; Isamu,Sugimoto ^[2] ; Tomotaka,Okino ^[2] ; Nicholas C O,Tomkinson ^[3] ; Luke H,Chamberlain ^[4]

作者单位： Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom. Electronic address: Christine.salaun@strath.ac.uk. ^[1] Ono Pharmaceutical Co Ltd, Osaka, Japan. ^[2] Department of Pure and Applied Chemistry, University of Strathclyde, Glasgow, United Kingdom. ^[3] Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom. ^[4]

关键词 PSD95 SNAP25 acyltransferase chemical inhibitor click chemistry high-throughput screening protein acylation protein palmitoylation zDHHC enzymes zDHHC2

主题词人类(Humans);酰化作用(Acylation);酰基转移酶类(Acyltransferases);半胱氨酸(Cysteine);脂化作用(Lipoylation);锌指(Zinc Fingers);药物发现(Drug Discovery)

DOI 10.1016/j.jbc.2022.102469

PMID 36087837

发布时间 2022-11-30

翻译满意度评价：

准确一般字义偏差语意偏离译文作用小提交