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AAV-monoclonal antibody expression protects mice from Ebola virus without impeding the endogenous antibody response to heterologous challenge.

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第一作者： Laura P,van Lieshout

第一单位： Department of Pathobiology, University of Guelph, Guelph, ON N1G 2W1, Canada.

作者： Laura P,van Lieshout ^[1] ; Amira D,Rghei ^[1] ; Wenguang,Cao ^[2] ; Shihua,He ^[2] ; Geoff,Soule ^[2] ; Wenjun,Zhu ^[2] ; Sylvia P,Thomas ^[1] ; Debra,Sorensen ^[3] ; Kathy,Frost ^[3] ; Kevin,Tierney ^[2] ; Brad,Thompson ^[4] ; Stephanie,Booth ^[5] ; David,Safronetz ^[6] ; Raveendra R,Kulkarni ^[7] ; Byram W,Bridle ^[1] ; Xiangguo,Qiu ^[2] ; Logan,Banadyga ^[2] ; Sarah K,Wootton ^[1]

作者单位： Department of Pathobiology, University of Guelph, Guelph, ON N1G 2W1, Canada. ^[1] Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, 1015 Arlington Street, Winnipeg, MB R3E 3R2, Canada. ^[2] Molecular Pathobiology, National Microbiology Laboratory, Public Health Agency of Canada, 1015 Arlington Street, Winnipeg, MB R3E 3R2, Canada. ^[3] Avamab Pharma Inc., 1646 Acton Avenue SW, Calgary, AB T2T 2P9, Canada. ^[4] Molecular Pathobiology, National Microbiology Laboratory, Public Health Agency of Canada, 1015 Arlington Street, Winnipeg, MB R3E 3R2, Canada.;Department of Medical Microbiology, University of Manitoba, Winnipeg, MB R3T 2N2, Canada. ^[5] Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, 1015 Arlington Street, Winnipeg, MB R3E 3R2, Canada.;Department of Medical Microbiology, University of Manitoba, Winnipeg, MB R3T 2N2, Canada. ^[6] Department of Pathobiology, University of Guelph, Guelph, ON N1G 2W1, Canada.;Department of Pathobiology and Population Health, North Carolina State University, Raleigh, NC 27695, USA. ^[7]

关键词 AAV6.2FF Ebola adeno-associated virus (AAV)filovirus immunotherapy monoclonal antibody vectored immunoprophylaxis

DOI 10.1016/j.omtm.2022.08.003

PMID 36092367

发布时间 2022-09-13

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Molecular therapy. Methods & clinical development

2022年26卷

505-518页

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Molecular therapy. Methods & clinical development

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AAV-monoclonal antibody expression protects mice from Ebola virus without impeding the endogenous antibody response to heterologous challenge.

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AAV-monoclonal antibody expression protects mice from Ebola virus without impeding the endogenous antibody response to heterologous challenge.

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