Targeting trafficking as a therapeutic avenue for misfolded GPCRs leading to endocrine diseases.

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作者： Alfredo,Ulloa-Aguirre ^[1] ; Teresa,Zariñán ^[1] ; Rubén,Gutiérrez-Sagal ^[1] ; Ya-Xiong,Tao ^[2]

作者单位： Red de Apoyo a la Investigación (RAI), National University of Mexico and Instituto Nacional de Ciencias Médicas y Nutrición SZ, Mexico City, Mexico. ^[1] Department of Anatomy, Physiology & Pharmacology, Auburn University College of Veterinary Medicine, Auburn, AL, United States. ^[2]

关键词 G protein-coupled receptors GPCRs intracellular trafficking molecular chaperones pharmacological chaperones pharmacoperones quality control system

主题词细胞膜(Cell Membrane);内分泌系统疾病(Endocrine System Diseases);人类(Humans);婴儿, 新生(Infant, Newborn);突变(Mutation);蛋白质折叠(Protein Folding);受体, G-蛋白偶联(Receptors, G-Protein-Coupled)

DOI 10.3389/fendo.2022.934685

PMID 36093106

发布时间 2022-09-13

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准确一般字义偏差语意偏离译文作用小提交