首页> Journal of virology> HIV-1 Preintegration Complex Preferentially Integrates the Viral DNA into Nucleosomes Containing Trimethylated Histone 3-Lysine 36 Modification and Flanking Linker DNA.

HIV-1 Preintegration Complex Preferentially Integrates the Viral DNA into Nucleosomes Containing Trimethylated Histone 3-Lysine 36 Modification and Flanking Linker DNA.

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第一作者： Nicklas,Sapp

第一单位： The Center for AIDS Health Disparities Research, Meharry Medical Collegegrid.259870.1, Nashville, Tennessee, USA.;Department of Biochemistry, Cancer Biology, Pharmacology, and Neuroscience, Meharry Medical Collegegrid.259870.1, Nashville, Tennessee, USA.;School of Graduate Studies and Research, Meharry Medical Collegegrid.259870.1, Nashville, Tennessee, USA.

作者： Nicklas,Sapp ^[1] ; Nathaniel,Burge ^[2] ; Khan,Cox ^[3] ; Prem,Prakash ^[4] ; Muthukumar,Balasubramaniam ^[4] ; Santosh,Thapa ^[4] ; Devin,Christensen ^[5] ; Min,Li ^[6] ; Jared,Linderberger ^[7] ; Mamuka,Kvaratskhelia ^[7] ; Jui,Pandhare ^[8] ; Robert,Craigie ^[6] ; Michael G,Poirier ^[9] ; Chandravanu,Dash ^[4]

作者单位： The Center for AIDS Health Disparities Research, Meharry Medical Collegegrid.259870.1, Nashville, Tennessee, USA.;Department of Biochemistry, Cancer Biology, Pharmacology, and Neuroscience, Meharry Medical Collegegrid.259870.1, Nashville, Tennessee, USA.;School of Graduate Studies and Research, Meharry Medical Collegegrid.259870.1, Nashville, Tennessee, USA. ^[1] Department of Chemistry and Biochemistry, Ohio State University, Columbus, Ohio, USA.;Department of Physics, Ohio State University, Columbus, Ohio, USA. ^[2] Department of Chemistry and Biochemistry, Ohio State University, Columbus, Ohio, USA.;Department of Physics, Ohio State University, Columbus, Ohio, USA.;Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA. ^[3] The Center for AIDS Health Disparities Research, Meharry Medical Collegegrid.259870.1, Nashville, Tennessee, USA.;Department of Biochemistry, Cancer Biology, Pharmacology, and Neuroscience, Meharry Medical Collegegrid.259870.1, Nashville, Tennessee, USA. ^[4] Department of Biochemistry, University of Utah, Salt Lake City, Utah, USA. ^[5] Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA. ^[6] Division of Infectious Diseases, University of Colorado, Aurora, Colorado, USA. ^[7] The Center for AIDS Health Disparities Research, Meharry Medical Collegegrid.259870.1, Nashville, Tennessee, USA.;School of Graduate Studies and Research, Meharry Medical Collegegrid.259870.1, Nashville, Tennessee, USA.;Department of Microbiology, Immunology, and Physiology, Meharry Medical Collegegrid.259870.1, Nashville, Tennessee, USA. ^[8] Department of Microbiology, Immunology, and Physiology, Meharry Medical Collegegrid.259870.1, Nashville, Tennessee, USA.;Department of Chemistry and Biochemistry, Ohio State University, Columbus, Ohio, USA.;Department of Physics, Ohio State University, Columbus, Ohio, USA. ^[9]

关键词 H3K36me3 HIV PIC PTM chromatin histone human immunodeficiency virus intasome integration nucleosome posttranslational modification preintegration complex