Tumor-derived interleukin-34 creates an immunosuppressive and chemoresistant tumor microenvironment by modulating myeloid-derived suppressor cells in triple-negative breast cancer.

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作者： Nabeel,Kajihara ^[1] ; Takuto,Kobayashi ^[1] ; Ryo,Otsuka ^[1] ; Junko,Nio-Kobayashi ^[2] ; Tomohiro,Oshino ^[3] ; Masato,Takahashi ^[3] ; Seiichi,Imanishi ^[4] ; Ari,Hashimoto ^[5] ; Haruka,Wada ^[1] ; Ken-Ichiro,Seino ^[6]

作者单位： Division of Immunobiology, Graduate School of Medicine, Institute for Genetic Medicine, Hokkaido University, Kita-15 Nishi-7, Kita-ku, Sapporo city, Hokkaido, 060-0815, Japan. ^[1] Laboratory of Histology and Cytology, Graduate School of Medicine, Hokkaido University, Kita-15 Nishi-7, Kita-ku, Sapporo city, Hokkaido, 060-8638, Japan. ^[2] Department of Breast Surgery, Hokkaido University Hospital, Kita-14 Nishi-5, Kita-ku, Sapporo city, Hokkaido, 060-8648, Japan. ^[3] Department of Breast Surgery, Osaka Rosai Hospital, Nagasone-cho 1179-3, Kita-ku, Sakai city, Osaka, 591-8025, Japan. ^[4] Department of Molecular Biology, Faculty of Medicine, Hokkaido University, Kita-15 Nishi-7, Kita-ku, Sapporo city, Hokkaido, 060-8638, Japan. ^[5] Division of Immunobiology, Graduate School of Medicine, Institute for Genetic Medicine, Hokkaido University, Kita-15 Nishi-7, Kita-ku, Sapporo city, Hokkaido, 060-0815, Japan. seino@igm.hokudai.ac.jp. ^[6]

关键词 4T1 Chemotherapy Interleukin-34 Myeloid-derived suppressor cells Triple-negative breast cancer Tumor microenvironment

主题词人类(Humans);肿瘤微环境(Tumor Microenvironment);T淋巴细胞, 调节性(T-Lymphocytes, Regulatory);白细胞介素类(Interleukins)

DOI 10.1007/s00262-022-03293-3

PMID 36104597

发布时间 2024-04-26

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