Discovery and Crystallographic Studies of Trisubstituted Piperazine Derivatives as Non-Covalent SARS-CoV-2 Main Protease Inhibitors with High Target Specificity and Low Toxicity.

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作者： Shenghua,Gao ^[1] ; Katharina,Sylvester ^[2] ; Letian,Song ^[3] ; Tobias,Claff ^[1] ; Lanlan,Jing ^[3] ; Molly,Woodson ^[1] ; Renato H,Weiße ^[4] ; Yusen,Cheng ^[5] ; Laura,Schäkel ^[6] ; Marvin,Petry ^[1] ; Michael,Gütschow ^[3] ; Anke C,Schiedel ^[3] ; Norbert,Sträter ^[3] ; Dongwei,Kang ^[3] ; Shujing,Xu ^[6] ; Karoly,Toth ^[1] ; John,Tavis ^[1] ; Ann E,Tollefson ^[4] ; Christa E,Müller ^[5] ; Xinyong,Liu ^[4] ; Peng,Zhan ^[5]

作者单位： Department of Medicinal Chemistry, Key Laboratory of Chemical Biology, Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Ji'nan 250012, China. ^[1] Shenzhen Research Institute of Shandong University, A301 Virtual University Park in South District of Shenzhen, Guangdong 518057, P. R. China. ^[2] PharmaCenter Bonn & Pharmaceutical Institute, Department of Pharmaceutical & Medicinal Chemistry, University of Bonn, An der Immenburg 4, Bonn 53113, Germany. ^[3] Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, St. Louis, Missouri 63103, United States. ^[4] Saint Louis University Institute for Drug and Biotherapeutic Innovation, St. Louis, Missouri 63103, United States. ^[5] Institute of Bioanalytical Chemistry, Center for Biotechnology and Biomedicine, Leipzig University, Deutscher Platz 5, Leipzig 04103, Germany. ^[6]