CRISPR/Cas9 based blockade of IL-10 signaling impairs lipid and tissue homeostasis to accelerate atherosclerosis.

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第一作者： Haozhe,Shi

第一单位： Institute of Cardiovascular Sciences and Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, School of Basic Medical Sciences, Peking University, Beijing, China.

作者： Haozhe,Shi ^[1] ; Jiabao,Guo ^[1] ; Qiongyang,Yu ^[1] ; Xinlin,Hou ^[2] ; Lili,Liu ^[2] ; Mingming,Gao ^[3] ; Lili,Wei ^[4] ; Ling,Zhang ^[1] ; Wei,Huang ^[1] ; Yuhui,Wang ^[1] ; George,Liu ^[1] ; Peter,Tontonoz ^[5] ; Xunde,Xian ^[6]

作者单位： Institute of Cardiovascular Sciences and Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, School of Basic Medical Sciences, Peking University, Beijing, China. ^[1] Department of Pediatrics, Peking University First Hospital, Beijing, China. ^[2] Laboratory of Lipid Metabolism, Institute of Basic Medicine, Hebei Medical University, Shijiazhuang, China. ^[3] School of Medicine, Shihezi University, Shihezi City, China. ^[4] Department of Pathology, University of California, Los Angeles, CA, United States. ^[5] Department of Biological Chemistry, University of California, Los Angeles, CA, United States. ^[6] Beijing Key Laboratory of Cardiovascular Receptors Research, Peking University Third Hospital, Beijing, China. ^[7]

关键词 CRISPR/Cas9 Syrian golden hamster atherosclerosis gut microbiota interleukin-10