Gamma-aminobutyric acid (GABA) levels in the midcingulate cortex and clozapine response in patients with treatment-resistant schizophrenia: A proton magnetic resonance spectroscopy (<sup>1</sup> H-MRS) study.

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第一作者： Fumihiko,Ueno

第一单位： Brain Health Imaging Centre, Centre for Addiction and Mental Health (CAMH), Toronto, Ontario, Canada.

作者： Fumihiko,Ueno ^[1] ; Shinichiro,Nakajima ^[2] ; Yusuke,Iwata ^[3] ; Shiori,Honda ^[1] ; Edgardo,Torres-Carmona ^[2] ; Wanna,Mar ^[4] ; Sakiko,Tsugawa ^[2] ; Peter,Truong ^[1] ; Eric,Plitman ^[5] ; Yoshihiro,Noda ^[1] ; Masaru,Mimura ^[2] ; Napapon,Sailasuta ^[1] ; Mark,Mikkelsen ^[3] ; Richard A E,Edden ^[2] ; Vincenzo,De Luca ^[2] ; Gary,Remington ^[6] ; Philip,Gerretsen ^[7] ; Ariel,Graff-Guerrero ^[8]

作者单位： Brain Health Imaging Centre, Centre for Addiction and Mental Health (CAMH), Toronto, Ontario, Canada. ^[1] Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan. ^[2] Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada. ^[3] Department of Neuropsychiatry, University of Yamanashi Faculty of Medicine, Chuo, Japan. ^[4] Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada. ^[5] Department of Tropical Medicine, University of Hawaii, Honolulu, Hawaii, USA. ^[6] Department of Radiology, Weill Cornell Medicine, New York, New York, USA. ^[7] Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. ^[8] F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland, USA. ^[9] Campbell Family Mental Health Research Institute, CAMH, Toronto, Ontario, Canada. ^[10]

关键词 1H-MRS Clozapine GABA MEGA-PRESS treatment-resistant schizophrenia

主题词人类(Humans);氯氮平(Clozapine);精神分裂症(Schizophrenia);γ氨基丁酸(gamma-Aminobutyric Acid)

DOI 10.1111/pcn.13463

PMID 36111425

发布时间 2022-11-08

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