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DPP9 deficiency: An inflammasomopathy that can be rescued by lowering NLRP1/IL-1 signaling.

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作者单位: Inflammation Division, the Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.;Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia. [1] Skin Research Institute of Singapore (SRIS), A*STAR, Singapore, Singapore.;Skin Research Laboratories (ASRL), A*STAR, Singapore, Singapore. [2] Laboratory of Human Genetics and Therapeutics, Genome Institute of Singapore (GIS), A*STAR, Singapore, Singapore. [3] the Institute for Rare Diseases, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. [4] St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, the Rockefeller University, New York, NY, USA.;Paris University, Imagine Institute, Paris, France.;Laboratory of Human Genetics of Infectious Disease, Necker Branch, INSERM U1163, Paris, France. [5] St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, the Rockefeller University, New York, NY, USA. [6] Center for Undiagnosed Diseases, Stanford University School of Medicine, Stanford, CA, USA. [7] Skin Research Institute of Singapore (SRIS), A*STAR, Singapore, Singapore. [8] Centenary Institute, the University of Sydney Faculty of Medicine and Health, Sydney, New South Wales, Australia. [9] Department of Pathology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. [10] Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Harvard Medical School, Boston, MA, USA.;Department of Pediatrics, Dr. von Hauner Children's Hospital, LMU Klinikum Munich, Munich, Germany. [11] the Rina Zaizov Hematology-Oncology Division, Schneider Children's Medical Center of Israel, Felsenstein Medical Research Center, Tel Aviv University, Tel Aviv, Israel. [12] Department of Pediatric Hemato-Oncology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel. [13] Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.;Division of Genetics and Genomics, Boston Children's Hospital, Boston, MA, USA. [14] Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Harvard Medical School, Boston, MA, USA. [15] Medical Genetics Department, Koç University School of Medicine (KUSOM), Istanbul, Turkey. [16] Department of Pediatric Infection, Health Science University, Bakırköy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey. [17] St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, the Rockefeller University, New York, NY, USA.;Paris University, Imagine Institute, Paris, France.;Laboratory of Human Genetics of Infectious Disease, Necker Branch, INSERM U1163, Paris, France.;Pediatric Immunology-Hematology Unit, Assistance Publique-Hôpitaux de Paris, Necker Hospital for Sick Children, Paris, France.;Howard Hughes Medical Institute, New York, NY, USA. [18] Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA. [19] Skin Research Institute of Singapore (SRIS), A*STAR, Singapore, Singapore.;Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore. [20] Laboratory of Human Genetics and Therapeutics, Genome Institute of Singapore (GIS), A*STAR, Singapore, Singapore.;Medical Genetics Department, Koç University School of Medicine (KUSOM), Istanbul, Turkey.;Laboratory of Human Genetics and Therapeutics, Institute of Molecular and Cellular Biology (IMCB), A*STAR, Singapore, Singapore.;Smart-Health Initiative, Biological and Environmental Sciences and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia. [21]
DOI 10.1126/sciimmunol.abi4611
PMID 36112693
发布时间 2024-09-11
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Science immunology

Science immunology

2022年7卷75期

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